Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3750586 | 0.82 | DPP4 (0.46) | DPP4S1PR1NOS3NOS1NOS2 | |
| SCHEMBL3756401 | 0.79 | DPP4 (0.62) | SYKDPP4HTR7FFAR1FFAR4 | |
| Hydrochloric Acid SCHEMBL12490497 | 0.78 | DPP4 (0.60) | SYKDPP4HTR7FFAR1FFAR4 | |
| SCHEMBL11691477 | 0.76 | SYK (0.48) | SYKFFAR4ABL1ABCB1BCR | |
| SCHEMBL1038044 | 0.75 | DPP4 (0.69) | SYKDPP4HTR7FFAR1FFAR4 | |
| SCHEMBL3944796 | 0.73 | SYK (0.36) | SYKS1PR1ABL1ABCB1BCR | |
| SCHEMBL15832032 | 0.72 | SYK (0.46) | SYKABL1ABCB1BCRCD274 | |
| SCHEMBL3723618 | 0.72 | DPP4 (0.69) | DPP4HTR7FFAR1FFAR4ABL1 | |
| SCHEMBL27579640 | 0.71 | MAOB (0.42) | KIF11 | |
| SCHEMBL7956009 | 0.68 | PTGDR2 (0.52) | HTR7FFAR1FFAR4ABL1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |