Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944792 | 0.73 | SYK (0.42) | SYKABL1ABCB1BCRS1PR1 | |
| SCHEMBL11691477 | 0.71 | SYK (0.48) | SYKABL1ABCB1BCRMEN1 | |
| SCHEMBL24767596 | 0.63 | CYP1A1 (0.48) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL13463285 | 0.63 | ACHE (0.56) | ABL1ABCB1BCRMEN1KMT2A | |
| SCHEMBL29143057 | 0.62 | ACHE (0.47) | ABL1ABCB1BCRMEN1KMT2A | |
| SCHEMBL10068337 | 0.62 | ACHE (0.54) | ABL1ABCB1BCRMEN1KMT2A | |
| SCHEMBL6688815 | 0.62 | ACHE (0.60) | ABL1ABCB1BCRMEN1KMT2A | |
| SCHEMBL172439 | 0.62 | ACHE (0.60) | ABL1ABCB1BCRKMT2AMAPT | |
| SCHEMBL12345146 | 0.62 | ACHE (0.54) | SYKABL1ABCB1BCRKMT2A | |
| SCHEMBL4567631 | 0.61 | ACHE (0.54) | ABL1ABCB1BCRKMT2AALKBH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |