Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | BCR | P11274 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL12490497 | 0.98 | DPP4 (0.60) | DPP4ABL1ABCB1BCRHTR7 | |
| SCHEMBL1520607 | 0.83 | ABL1 (0.56) | ABL1ABCB1BCRHTR7HDAC4 | |
| SCHEMBL13675365 | 0.83 | ABL1 (0.56) | ABL1ABCB1BCRHTR7HDAC4 | |
| SCHEMBL8529161 | 0.81 | ABL1 (0.55) | ABL1ABCB1BCRHTR7HDAC4 | |
| SCHEMBL28792762 | 0.81 | ABL1 (0.55) | ABL1ABCB1BCRHTR7HDAC4 | |
| SCHEMBL10821571 | 0.81 | ABL1 (0.55) | ABL1ABCB1BCRHTR7HDAC4 | |
| SCHEMBL8279410 | 0.81 | MGAT2 (0.57) | DPP4ABCB1HTR7MAPTTSHR | |
| SCHEMBL4375331 | 0.80 | PPARA (0.53) | ABL1ABCB1BCRHTR7HDAC4 | |
| Hydrochloric Acid SCHEMBL12490805 | 0.80 | MGAT2 (0.56) | DPP4ABCB1HTR7MAPTMAOB | |
| SCHEMBL12715050 | 0.80 | ABL1 (0.79) | ABL1ABCB1BCRHTR7HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015089137-A1 | ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| US-20120270875-A1 | PYRIMIDINE AMIDE COMPOUNDS | GILLESPIE PAUL (US) | 2012-10-25 | — | — | US | disclosed |
| US-20120270875-A1 | PYRIMIDINE AMIDE COMPOUNDS | GILLESPIE PAUL (US) | 2012-10-25 | — | — | US | disclosed |
| WO-2012123467-A1 | PYRIMIDINE AMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-20 | — | — | WO | disclosed |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | disclosed |
| US-20080275078-A1 | Pyrazolo[3,4-B] Pyridine Compounds and Their Use as Pde4 Inhibitors | GLAXO GROUP LIMITED (GB) | 2008-11-06 | — | — | US | disclosed |
| US-20080015237-A1 | NEW COMPOUNDS I/418 | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | US | disclosed |
| US-5278191-A | Nervous system disorders | G. D. SEARLE & CO. (US) | 1994-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270875-A1 | PYRIMIDINE AMIDE COMPOUNDS | UMPS, TYMS, DPYD | DPP4 1530/4885ABL1 1106/4885ABCB1 1072/4885 |
| US-20080275078-A1 | Pyrazolo[3,4-B] Pyridine Compounds and Their Use as Pde4 Inhibitors | PDE4B, PDE3B, PDE4A | DPP4 37/4885ABL1 994/4885ABCB1 2115/4885 |
| US-20080015237-A1 | NEW COMPOUNDS I/418 | KCNH1, KCNH2, KCNH3 | DPP4 4206/4885ABL1 2396/4885ABCB1 236/4885 |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | KCNH1, KCNH2, KCNQ2 | DPP4 4521/4885ABL1 1004/4885ABCB1 313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.