Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | ICMT | O60725 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008767 | 0.90 | KDM4E (0.55) | MEN1KMT2AFAAHKDM4EALDH1A1 | |
| SCHEMBL4033276 | 0.90 | LTA4H (0.46) | MEN1KMT2AFAAHKDM4EMTNR1A | |
| SCHEMBL4036607 | 0.87 | MEN1 (0.43) | MEN1KMT2AFAAHKDM4EALDH1A1 | |
| SCHEMBL4036611 | 0.87 | MEN1 (0.43) | MEN1KMT2AFAAHKDM4EALDH1A1 | |
| SCHEMBL4038119 | 0.87 | TRPV1 (0.51) | MEN1KMT2AFAAHKDM4EALDH1A1 | |
| SCHEMBL3952437 | 0.87 | MTNR1A (0.44) | MEN1KMT2AFAAHKDM4EALDH1A1 | |
| SCHEMBL4038114 | 0.87 | TRPV1 (0.51) | MEN1KMT2AFAAHKDM4EALDH1A1 | |
| SCHEMBL3950827 | 0.83 | ICMT (0.49) | MEN1KMT2AKDM4EALDH1A1ICMT | |
| SCHEMBL1081600 | 0.81 | KDM4E (0.59) | MEN1KMT2AFAAHKDM4EALDH1A1 | |
| SCHEMBL4688784 | 0.80 | SCN9A (0.44) | MEN1KMT2AFAAHKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024613-A1 | TETRACYCLIC INDOLOPYRIDINES AS EG5 INHIBITORS | 4SC AG (DE) | 2009-02-26 | — | — | WO | disclosed |
| EP-1996592-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | Nycomed GmbH (DE) | 2008-12-03 | — | — | EP | disclosed |
| EP-1994033-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007096395-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007096393-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2007-08-30 | — | — | WO | disclosed |