Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.73 |
| ▸ | MTOR | P42345 | 1/20 | 0.73 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.69 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.64 |
| ▸ | IDH1 | O75874 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255088 | 0.84 | MTOR (1.00) | BAZ1AMEN1MAPTKMT2ARAB9A | |
| SCHEMBL6376812 | 0.84 | KMT2A (0.79) | BAZ1AMEN1MAPTKMT2ARAB9A | |
| SCHEMBL18031166 | 0.83 | EPHX2 (0.85) | BAZ1AMEN1MAPTKMT2ARAB9A | |
| SCHEMBL4548071 | 0.83 | EPHX2 (0.85) | BAZ1AMEN1MAPTKMT2ARAB9A | |
| SCHEMBL26625460 | 0.83 | MTOR (0.71) | BAZ1AMEN1MAPTKMT2ARAB9A | |
| SCHEMBL3429571 | 0.83 | BAZ1A (0.71) | BAZ1AMEN1MAPTKMT2ARAB9A | |
| SCHEMBL3429577 | 0.83 | BAZ1A (0.71) | BAZ1AMEN1MAPTKMT2ARAB9A | |
| SCHEMBL30969167 | 0.83 | PTGS1 (0.74) | BAZ1AMEN1MAPTKMT2ARAB9A | |
| SCHEMBL161516 | 0.83 | BAZ1A (0.71) | BAZ1AMEN1MAPTKMT2ARAB9A | |
| SCHEMBL28729179 | 0.83 | EPHX2 (1.00) | BAZ1AMEN1MAPTKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049541-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-04-22 | — | — | EP | claimed |
| WO-2008016192-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-02-07 | — | — | WO | claimed |
| EP-2049541-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008016192-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-02-07 | — | — | WO | disclosed |