Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24303626 | 0.79 | APLNR (0.41) | APLNRMEN1KMT2AGRIN2BGRIN1 | |
| SCHEMBL24303629 | 0.79 | APLNR (0.43) | APLNRMEN1KMT2AGRIN2BGRIN1 | |
| SCHEMBL20449465 | 0.78 | MEN1 (0.34) | MEN1KMT2AGRIN2BGRIN1SIGMAR1 | |
| SCHEMBL3946528 | 0.75 | APLNR (0.34) | APLNRHDAC6 | |
| SCHEMBL3238372 | 0.75 | DAO (0.36) | — | |
| SCHEMBL18224526 | 0.74 | APLNR (0.46) | APLNRGRIN2BGRIN1SIGMAR1KDM4E | |
| SCHEMBL4184545 | 0.73 | APLNR (0.38) | APLNRNR1I2 | |
| SCHEMBL3238364 | 0.73 | HDAC6 (0.41) | APLNRHDAC6NR1I2 | |
| SCHEMBL346024 | 0.73 | HDAC6 (0.41) | APLNRHDAC6NR1I2 | |
| SCHEMBL3941882 | 0.72 | CNR1 (0.34) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095712-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-06 | — | — | WO | disclosed |
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |