Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4184543 | 0.76 | APLNR (0.38) | APLNRNTRK1ALKALDH1A1 | |
| SCHEMBL4566085 | 0.74 | HDAC6 (0.30) | — | |
| SCHEMBL1439309 | 0.74 | HDAC6 (0.30) | — | |
| SCHEMBL3946534 | 0.73 | APLNR (0.37) | APLNRNR1I2 | |
| Hydrochloric Acid SCHEMBL3946082 | 0.72 | APLNR (0.49) | APLNRNTRK1ALKALDH1A1PTGS2 | |
| SCHEMBL3238364 | 0.71 | HDAC6 (0.41) | APLNRNTRK1ALKNR1I2JAK2 | |
| SCHEMBL346024 | 0.71 | HDAC6 (0.41) | APLNRNTRK1ALKNR1I2JAK2 | |
| SCHEMBL4324172 | 0.68 | APLNR (0.35) | APLNRNTRK1NR1I2 | |
| SCHEMBL4023097 | 0.68 | APLNR (0.35) | APLNRALDH1A1NR1I2 | |
| SCHEMBL24707419 | 0.68 | APLNR (0.33) | APLNRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |