Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SKP2 | Q13309 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.49 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.49 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7529710 | 0.93 | SKP2 (0.50) | SKP2CYP3A4CYP2D6CYP2C9CYP1A2 | |
| SCHEMBL16901836 | 0.84 | SKP2 (0.56) | SKP2CYP3A4CYP2D6CYP2C9CYP1A2 | |
| SCHEMBL31099583 | 0.84 | SKP2 (0.56) | SKP2CYP3A4CYP2D6CYP2C9CYP1A2 | |
| SCHEMBL676926 | 0.81 | SKP2 (0.44) | SKP2CYP3A4CYP2D6CYP2C9CYP1A2 | |
| SCHEMBL10822814 | 0.80 | SMN1; SMN2 (0.42) | SKP2CYP1A2HPGDNPC1MAPK1 | |
| SCHEMBL5838115 | 0.78 | SKP2 (0.68) | SKP2CYP3A4CYP2D6CYP2C9CYP1A2 | |
| SCHEMBL17160010 | 0.77 | SKP2 (0.49) | SKP2CYP3A4CYP2D6CYP2C9CYP1A2 | |
| SCHEMBL8371448 | 0.77 | SKP2 (0.49) | SKP2CYP3A4CYP2D6CYP2C9CYP1A2 | |
| SCHEMBL11806384 | 0.77 | CDK1 (0.51) | SKP2CYP3A4ALDH1A1HSD17B10KDM4E | |
| SCHEMBL677637 | 0.76 | TLR8 (0.48) | CYP3A4NPC1MAPK1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895560-B2 | Opioid antagonists | ADOLOR CORPORATION (US) | 2014-11-25 | — | — | US | disclosed |
| US-20140186951-A1 | NOVEL OPIOID ANTAGONISTS | ADOLOR CORPORATION (US) | 2014-07-03 | — | — | US | disclosed |
| US-20130317035-A1 | NOVEL OPIOID ANTAGONISTS | ADOLOR CORPORATION (US) | 2013-11-28 | — | — | US | disclosed |
| US-8580788-B2 | Opioid antagonists | ADOLOR CORPORATION (US) | 2013-11-12 | — | — | US | disclosed |
| EP-1940412-B1 | NOVEL OPIOID ANTAGONISTS | ADOLOR CORP (US) | 2013-01-23 | — | — | EP | disclosed |
| US-8278323-B2 | Opioid antagonists | ADOLOR CORPORATION (US) | 2012-10-02 | — | — | US | disclosed |
| US-20120231543-A1 | NOVEL OPIOID ANTAGONISTS | ADOLOR CORPORATION (US) | 2012-09-13 | — | — | US | disclosed |
| US-20090221562-A1 | NOVEL OPIOID ANTAGONISTS | ADOLOR CORPORATION (US) | 2009-09-03 | — | — | US | disclosed |
| US-7544676-B2 | Sulfamoyl benzamides and methods of their use | ADOLOR CORPORATION (US) | 2009-06-09 | — | — | US | disclosed |
| US-7538110-B2 | e.g. 1-(8-(3-hydroxyphenyl)-7,8-dimethyl-hexahydro-1H-pyrido[1,2- alpha ]pyrazin-2(6H)-yl)-2-phenylethanone; analgesics; gastrointestinal dysfunction, post-surgical recovery; side effect reduction | ADOLOR CORPORATION (US) | 2009-05-26 | — | — | US | disclosed |
| US-20080058302-A1 | Sulfamoyl Benzamides and Methods of Their Use | CALIXA THERAPEUTICS, INC. | 2008-03-06 | — | — | US | disclosed |
| US-20070105863-A1 | e.g. 1-(8-(3-hydroxyphenyl)-7,8-dimethyl-hexahydro-1H-pyrido[1,2- alpha ]pyrazin-2(6H)-yl)-2-phenylethanone; analgesics; gastrointestinal dysfunction, post-surgical recovery; side effect reduction | MERCK SHARP & DOHME LLC | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120231543-A1 | NOVEL OPIOID ANTAGONISTS | OPRK1, OPRM1, OPRL1 | SKP2 3406/4885CYP3A4 299/4885CYP2D6 206/4885 |
| US-20130317035-A1 | NOVEL OPIOID ANTAGONISTS | OPRK1, OPRM1, OPRL1 | SKP2 3406/4885CYP3A4 299/4885CYP2D6 206/4885 |
| US-20090221562-A1 | NOVEL OPIOID ANTAGONISTS | OPRK1, OPRM1, OPRL1 | SKP2 3406/4885CYP3A4 299/4885CYP2D6 206/4885 |
| US-20080058302-A1 | Sulfamoyl Benzamides and Methods of Their Use | CNR2, TRPV1, CNR1 | SKP2 2584/4885CYP3A4 4418/4885CYP2D6 4410/4885 |
| US-20070105863-A1 | e.g. 1-(8-(3-hydroxyphenyl)-7,8-dimethyl-hexahydro-1H-pyrido[1,2- alpha ]pyrazin-2(6H)-yl)-2-phenylethanone; analgesics; gastrointestinal dysfunction, post-surgical recovery; side effect reduction | OPRK1, OPRD1, OPRM1 | SKP2 1011/4885CYP3A4 38/4885CYP2D6 24/4885 |
| US-20140186951-A1 | NOVEL OPIOID ANTAGONISTS | OPRK1, OPRM1, OPRL1 | SKP2 3406/4885CYP3A4 299/4885CYP2D6 206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.