Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3949521 | 0.92 | SSTR5 (0.40) | SSTR5HTR3AALDH1A1ROCK1DYRK1A | |
| SCHEMBL3957845 | 0.91 | HTR3A (0.34) | SSTR5HTR3AALDH1A1ROCK1DYRK1A | |
| SCHEMBL3958440 | 0.84 | SSTR5 (0.39) | SSTR5HTR3AALDH1A1ROCK1DYRK1A | |
| SCHEMBL3951943 | 0.84 | HTR3A (0.33) | SSTR5HTR3AALDH1A1ROCK1DYRK1A | |
| SCHEMBL3953112 | 0.83 | HTR3A (0.34) | SSTR5HTR3AALDH1A1ROCK1DYRK1A | |
| SCHEMBL3951679 | 0.82 | TSPO (0.34) | HTR3AALDH1A1ROCK1DYRK1AKDM4E | |
| SCHEMBL2212451 | 0.82 | SSTR5 (0.49) | SSTR5HTR3AALDH1A1DYRK1APTGER4 | |
| SCHEMBL3953382 | 0.80 | SSTR5 (0.44) | SSTR5HTR3AALDH1A1ROCK1DYRK1A | |
| SCHEMBL2208705 | 0.79 | SSTR5 (0.43) | SSTR5HTR3AALDH1A1ROCK1DYRK1A | |
| SCHEMBL2205523 | 0.78 | SSTR5 (0.42) | SSTR5HTR3AALDH1A1ROCK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7563816-B2 | Ophthalmic compositions for treating ocular hypertension | MERCK & CO. INC. (US) | 2009-07-21 | — | — | US | claimed |
| US-20080032951-A1 | Ophthalmic Compositions For Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2008-02-07 | — | — | US | claimed |
| US-7563816-B2 | Ophthalmic compositions for treating ocular hypertension | MERCK & CO. INC. (US) | 2009-07-21 | — | — | US | disclosed |
| US-7563816-B2 | Ophthalmic compositions for treating ocular hypertension | MERCK & CO. INC. (US) | 2009-07-21 | — | — | US | disclosed |
| US-7563816-B2 | Ophthalmic compositions for treating ocular hypertension | MERCK & CO. INC. (US) | 2009-07-21 | — | — | US | disclosed |
| EP-1771170-A4 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2009-07-08 | — | — | EP | disclosed |
| US-20080032951-A1 | Ophthalmic Compositions For Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2008-02-07 | — | — | US | disclosed |
| US-20080032951-A1 | Ophthalmic Compositions For Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2008-02-07 | — | — | US | disclosed |
| US-20080032951-A1 | Ophthalmic Compositions For Treating Ocular Hypertension | MERCK SHARP & DOHME CORP. | 2008-02-07 | — | — | US | disclosed |
| EP-1771170-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006020003-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080032951-A1 | Ophthalmic Compositions For Treating Ocular Hypertension | KCNH2, KCNN1, KCNH3 | SSTR5 880/4885HTR3A 2037/4885ALDH1A1 979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.