Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 3/20 | 0.50 |
| ▸ | ADH1A | P07327 | 3/20 | 0.50 |
| ▸ | ADH7 | P40394 | 3/20 | 0.50 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.50 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.50 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.50 |
| ▸ | ADH1C | P00326 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | ADH4 | P08319 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14431493 | 0.89 | — | — | |
| SCHEMBL3950791 | 0.88 | ADH1B (0.54) | ADH1BADH1AADH7GNAI3GNAO1 | |
| SCHEMBL3925352 | 0.88 | GNAI3 (0.47) | ADH1BADH1AADH7GNAI3GNAO1 | |
| SCHEMBL1785087 | 0.85 | GNAI3 (0.44) | ADH1BADH1AADH7GNAI3GNAO1 | |
| SCHEMBL5748707 | 0.80 | — | — | |
| SCHEMBL1307631 | 0.80 | CARM1 (0.50) | ADH1BADH1AADH7GNAI3GNAO1 | |
| SCHEMBL4401317 | 0.80 | ACE2 (0.58) | ACE2SLC2A1DRD2SIGMAR1CARM1 | |
| SCHEMBL11315376 | 0.79 | CYP2C19 (0.41) | ADH1BADH1AADH7GNAI3GNAO1 | |
| SCHEMBL20407381 | 0.78 | ACE2 (0.52) | ADH1BADH1AADH7GNAI3GNAO1 | |
| SCHEMBL19981892 | 0.78 | CARM1 (0.48) | GNAI3GNAO1GNAI1SIGMAR1CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |