SCHEMBL3947865

SCHEMBL3947865

COCCN(C(=O)OC(C)(C)C)c1ncc(F)cc1F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F2 P00734 4/20 0.36
HDAC1 Q13547 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
SSTR4 P31391 2/20 0.33
NR3C2 P08235 1/20 0.32
ALDH1A1 P00352 2/20 0.32
KDM4E B2RXH2 1/20 0.32
HPGD P15428 1/20 0.32
HSD17B10 Q99714 1/20 0.32
LRRK2 Q5S007 3/20 0.32
BTK Q06187 1/20 0.32
CSNK2A1 P68400 1/20 0.31
GABRA1 P14867 1/20 0.31
GABRG2 P18507 1/20 0.31
GABRB3 P28472 1/20 0.31
GABRA5 P31644 1/20 0.31
GABRA3 P34903 1/20 0.31
GABRA2 P47869 1/20 0.31
GABRA4 P48169 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3939417 0.88 SSTR4 (0.41) F2HDAC1HDAC8HDAC6SSTR4
SCHEMBL3944952 0.83 HSD17B10 (0.37) HDAC1HDAC6ALDH1A1KDM4EHPGD
SCHEMBL2946714 0.72 SSTR4 (0.37) HDAC1HDAC8HDAC6SSTR4ALDH1A1
SCHEMBL12674816 0.72 ALDH1A1 (0.33) HDAC1HDAC8HDAC6ALDH1A1HPGD
SCHEMBL16215452 0.71 AAK1 (0.33) F2HDAC6SSTR4NR3C2MTNR1A
SCHEMBL17572193 0.71 AAK1 (0.39) HDAC6SSTR4ALDH1A1HPGDRAB9A
SCHEMBL12675113 0.70 ADORA2B (0.34) HDAC1HDAC8HDAC6SSTR4
SCHEMBL1794002 0.69 F2 (0.40) F2HDAC1HDAC8HDAC6ALDH1A1
SCHEMBL18519393 0.69 CSNK2A1 (0.35) F2SSTR4ALDH1A1KDM4EHPGD
SCHEMBL1009548 0.68 F2 (0.37) F2ALDH1A1KDM4EHPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009095712-A2 CHEMICAL COMPOUNDS ASTRAZENECA AB (SE) 2009-08-06 WO disclosed
WO-2009016410-A2 CHEMICAL COMPOUNDS 831 ASTRAZENECA AB (SE) 2009-02-05 WO disclosed
WO-2008132502-A1 PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER ASTRAZENECA AB (SE) 2008-11-06 WO disclosed