Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.31 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.31 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3951326 | 0.90 | ITGB3 (0.40) | ITGB3ITGA2BHRH3FAAHSLC6A4 | |
| SCHEMBL3950025 | 0.85 | HRH3 (0.40) | ITGB3ITGA2BHRH3FAAHSLC6A4 | |
| SCHEMBL6262811 | 0.81 | MEN1 (0.39) | ITGB3ITGA2BHRH3FAAHSLC6A4 | |
| SCHEMBL237382 | 0.80 | ITGB3 (0.47) | ITGB3ITGA2BHRH3FAAHSLC6A4 | |
| Hydrochloric Acid SCHEMBL10840761 | 0.78 | ITGB3 (0.46) | ITGB3ITGA2BHRH3FAAHSLC6A4 | |
| SCHEMBL8097693 | 0.78 | ITGB3 (0.46) | ITGB3ITGA2BHRH3FAAHSLC6A4 | |
| SCHEMBL3955642 | 0.77 | FAAH (0.37) | ITGB3ITGA2BFAAHGNAO1DRD4 | |
| SCHEMBL17540109 | 0.76 | DRD4 (0.32) | DRD4 | |
| SCHEMBL331124 | 0.75 | HRH3 (0.47) | ITGB3ITGA2BHRH3FAAHSLC6A4 | |
| SCHEMBL3948872 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |