Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956365 | 0.91 | GABRP (0.37) | FAAHGABRPGABRDGABRA1TSHR | |
| SCHEMBL3948876 | 0.77 | ITGB3 (0.37) | FAAHITGB3ITGA2BTPSAB1TPSD1 | |
| SCHEMBL10285 | 0.75 | KMT2A (0.36) | DRD4 | |
| SCHEMBL28327954 | 0.75 | LMNA (0.37) | TSHRPMP22ITGB3ITGA2B | |
| SCHEMBL27362445 | 0.71 | GABRP (0.46) | GABRPGABRDGABRA1TSHRGABRB1 | |
| SCHEMBL31275025 | 0.70 | GABRP (0.45) | GABRPGABRDGABRA1TSHRGABRB1 | |
| SCHEMBL30701348 | 0.69 | KMT2A (0.41) | — | |
| SCHEMBL27033108 | 0.69 | KDM5A (0.45) | TSHRPMP22ITGB3ITGA2B | |
| SCHEMBL16116680 | 0.69 | KDM5A (0.45) | TSHRPMP22ITGB3ITGA2B | |
| SCHEMBL3947564 | 0.68 | GABRA5 (0.52) | GABRPGABRDGABRA1TSHRGABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |