Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | CTSC | P53634 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | EDNRB | P24530 | 2/20 | 0.34 |
| ▸ | EDNRA | P25101 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3949555 | 0.86 | CTSL (0.51) | CTSLCTSSCTSKCTSCCTSB | |
| SCHEMBL3949052 | 0.84 | CTSL (0.46) | CTSLCTSSCTSKCTSCCTSB | |
| SCHEMBL3951319 | 0.83 | CTSL (0.44) | CTSLCTSSCTSKCTSCCTSB | |
| SCHEMBL3948515 | 0.83 | CTSL (0.45) | CTSLCTSSCTSKCTSCCTSB | |
| SCHEMBL3955669 | 0.82 | ALDH1A1 (0.44) | CTSLCTSSCTSKCTSCCTSB | |
| SCHEMBL3950831 | 0.80 | CTSL (0.43) | CTSLCTSSCTSKCTSCCTSB | |
| SCHEMBL3949447 | 0.80 | CTSL (0.41) | CTSLCTSSCTSKCTSCCTSB | |
| SCHEMBL3950858 | 0.80 | CTSL (0.41) | CTSLCTSSCTSKCTSCCTSB | |
| SCHEMBL3954226 | 0.77 | CTSL (0.40) | CTSLCTSSCTSKCTSCCTSB | |
| SCHEMBL3947754 | 0.76 | CTSL (0.42) | CTSLCTSSCTSKCTSCCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026197-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-02-26 | — | — | WO | disclosed |