Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | ESRRG | P62508 | 4/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | ESRRB | O95718 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067107 | 0.83 | CA2 (0.52) | CA2CA1NAMPTCTSSCTSK | |
| SCHEMBL20208984 | 0.80 | CTSS (0.50) | CA2CA1NAMPTCTSSCTSK | |
| SCHEMBL100146 | 0.80 | KDM4E (0.60) | CA2CA1NAMPTESRRGCTSS | |
| SCHEMBL27741035 | 0.80 | CA2 (0.56) | CA2CA1NAMPTCTSKMAPT | |
| SCHEMBL12283041 | 0.80 | NPC1 (0.60) | CA2CA1NAMPTMAPTTDP1 | |
| SCHEMBL1569661 | 0.80 | CA2 (0.56) | CA2CA1NAMPTCTSKMAPT | |
| SCHEMBL8757517 | 0.79 | CA2 (0.53) | CA2CA1NAMPTMAPTTDP1 | |
| SCHEMBL23449213 | 0.79 | CA2 (0.58) | CA2CA1NAMPTCTSKMAPT | |
| SCHEMBL13892916 | 0.79 | CA2 (0.55) | CA2CA1NAMPTCTSKMAPT | |
| SCHEMBL21521028 | 0.79 | CA2 (0.55) | CA2CA1NAMPTCTSKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051967-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECEPTOR TRPV1 RELATED DISORDERS | AstraZeneca AB (SE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008018827-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECEPTOR TRPV1 RELATED DISORDERS | ASTRAZENECA AB (SE) | 2008-02-14 | — | — | WO | disclosed |