Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3951701 | 0.91 | HIF1A (0.38) | PIM1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3950976 | 0.86 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL5362273 | 0.83 | — | — | |
| SCHEMBL3955016 | 0.83 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL19616839 | 0.83 | TSHR (0.35) | PIM1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL1616084 | 0.81 | — | — | |
| SCHEMBL972563 | 0.81 | KDM4E (0.46) | PIM1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL23775526 | 0.78 | KEAP1 (0.48) | SMN1; SMN2ACE2 | |
| SCHEMBL1306555 | 0.78 | HSD17B10 (0.46) | PIM1MEN1KMT2AALDH1A1KDM4E | |
| Fluoride SCHEMBL11245451 | 0.78 | KDM4E (0.50) | PIM1MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |