Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 5/20 | 0.40 |
| ▸ | GSK3B | P49841 | 10/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.39 |
| ▸ | CDK2 | P24941 | 7/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR1F | P30939 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3952939 | 0.91 | ATR (0.40) | ATRGSK3BCCNE2CCNE1CDK2 | |
| SCHEMBL3954321 | 0.87 | TYRO3 (0.42) | ATRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3469425 | 0.86 | HTT (0.43) | ATR | |
| SCHEMBL2497147 | 0.82 | BMPR1B (0.40) | — | |
| SCHEMBL3469349 | 0.76 | BMPR1B (0.39) | — | |
| SCHEMBL3469290 | 0.75 | BMPR1B (0.38) | — | |
| Hydrochloric Acid SCHEMBL3469292 | 0.75 | BMPR1B (0.38) | — | |
| SCHEMBL2497148 | 0.74 | ATR (0.34) | ATRHTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3950230 | 0.72 | FGFR1 (0.55) | — | |
| SCHEMBL3949893 | 0.70 | EGFR (0.44) | ATRCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |