Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372871 | 0.98 | HPGD (0.56) | HPGDALDH1A1TSHRHSD11B1SMN1; SMN2 | |
| SCHEMBL3060452 | 0.87 | HPGD (0.48) | HPGDALDH1A1TSHRHSD11B1SMN1; SMN2 | |
| SCHEMBL8860937 | 0.85 | HPGD (0.52) | HPGDALDH1A1TSHRHSD11B1SMN1; SMN2 | |
| SCHEMBL2200249 | 0.85 | HPGD (0.47) | HPGDALDH1A1TSHRHSD11B1SMN1; SMN2 | |
| SCHEMBL6132882 | 0.81 | ALDH1A1 (0.42) | HPGDALDH1A1TSHRHSD11B1SMN1; SMN2 | |
| SCHEMBL3557212 | 0.72 | HPGD (0.38) | HPGDALDH1A1TSHRHSD11B1 | |
| SCHEMBL3954353 | 0.72 | HPGD (0.38) | HPGDALDH1A1TSHRHSD11B1SMN1; SMN2 | |
| SCHEMBL3312314 | 0.72 | ALDH1A1 (0.42) | HPGDALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL2202337 | 0.71 | ALDH1A1 (0.41) | HPGDALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3920347 | 0.71 | HPGD (0.41) | HPGDALDH1A1TSHRHSD11B1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051974-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2009-04-29 | — | — | EP | claimed |
| WO-2008020045-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2008-02-21 | — | — | WO | claimed |
| EP-2051974-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008020045-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2008-02-21 | — | — | WO | disclosed |