Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.48 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.48 |
| ▸ | F3 | P13726 | 2/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3437188 | 1.00 | MAPT (0.48) | MAPTLMNAALDH1A1HDAC3HDAC4 | |
| Acrylonitrile SCHEMBL29191949 | 0.93 | KDM4E (0.44) | MAPTLMNAALDH1A1HDAC3HDAC4 | |
| SCHEMBL25633237 | 0.80 | MAPT (0.47) | MAPTALDH1A1CYP2C9SMN1; SMN2MAOB | |
| SCHEMBL6688122 | 0.79 | MAPT (0.54) | MAPTLMNAALDH1A1HDAC3HDAC4 | |
| SCHEMBL7935925 | 0.79 | MAPT (0.54) | MAPTLMNAALDH1A1HDAC3HDAC4 | |
| (Z)-1,2-Diphenylethene SCHEMBL4447909 | 0.78 | MCL1 (0.44) | MAPTLMNAALDH1A1HDAC3HDAC4 | |
| SCHEMBL21758829 | 0.76 | LMNA (0.42) | MAPTLMNAALDH1A1HDAC3HDAC4 | |
| Styrene SCHEMBL27564913 | 0.76 | ALDH1A1 (0.48) | MAPTALDH1A1HDAC8SMN1; SMN2TDP1 | |
| Styrene SCHEMBL10775344 | 0.76 | ALDH1A1 (0.48) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL551223 | 0.76 | MAPT (0.54) | MAPTLMNAALDH1A1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598419-B2 | Compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2009-10-06 | — | — | US | disclosed |
| EP-2043606-A2 | NANOPARTICULATE KINASE INHIBITOR FORMULATIONS | Elan Pharma International Limited (IE) | 2009-04-08 | — | — | EP | disclosed |
| CN-100413845-C | Compounds for modulating cell proliferation | HSC RES & DEV LTD (CA) | 2008-08-27 | — | — | CN | disclosed |
| WO-2007146943-A2 | NANOPARTICULATE KINASE INHIBITOR FORMULATIONS | ELAN PHARMA INTERNATIONAL LTD. (IE) | 2007-12-21 | — | — | WO | disclosed |
| US-20070243612-A1 | Novel Compounds for Modulating Cell Proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2007-10-18 | — | — | US | disclosed |
| EP-1727822-A4 | NOVEL COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2007-05-09 | — | — | EP | disclosed |
| EP-1752446-A3 | Compounds for modulating cell proliferation | HSC Research and Development Limited Partnership (CA) | 2007-03-21 | — | — | EP | disclosed |
| EP-1752446-A2 | Compounds for modulating cell proliferation | HSC Research and Development Limited Partnership (CA) | 2007-02-14 | — | — | EP | disclosed |
| WO-2007006143-A1 | COMPOSITIONS AND METHODS FOR DETECTING TRANSFORMED CELLS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-01-18 | — | — | WO | disclosed |
| EP-1272457-B9 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092904-A1 | NOVEL COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2005-10-06 | — | — | WO | disclosed |
| US-20040209845-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2004-10-21 | — | — | US | disclosed |
| US-6800659-B2 | NOVEL STYRYLACRYLONITRILE COMPOUNDS WHICH ARE USEFUL IN TREATING A VARIETY OF CELL PROLIFERATIVE DISORDERS SUCH AS CANCER ARE DISCLOSED. A METHOD OF MODULATING CELL PROLIFERATION COMPRISING ADMINISTERING AN EFFECTIVE AMOUNT OF | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2004-10-05 | — | — | US | disclosed |
| US-20040072803-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED (CA) | 2004-04-15 | — | — | US | disclosed |
| CN-1429202-A | Compounds for modulating cell proliferation | HSC RES & DEV LTD PARTNERSHIP (CA) | 2003-07-09 | — | — | CN | disclosed |
| US-20030109502-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2003-06-12 | — | — | US | disclosed |
| EP-1272457-A2 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC Research and Development Limited Partnership (CA) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001079158-A3 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2002-01-31 | — | — | WO | disclosed |
| WO-2001079158-A2 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2001-10-25 | — | — | WO | disclosed |
| US-3943161-A | Process for producing conjugated dienes containing a cyano group | TOYO SODA MANUFACTURING CO., LTD. (JA) | 1976-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070243612-A1 | Novel Compounds for Modulating Cell Proliferation | MKI67, CCNA1, PCNA | MAPT 4784/4885LMNA 2293/4885ALDH1A1 546/4885 |
| US-20040209845-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, CCNI | MAPT 4740/4885LMNA 1972/4885ALDH1A1 178/4885 |
| US-20030109502-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, CCNI | MAPT 4740/4885LMNA 1972/4885ALDH1A1 178/4885 |
| US-20040072803-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, MCL1 | MAPT 4762/4885LMNA 2144/4885ALDH1A1 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.