Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | DPYD | Q12882 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28482699 | 0.68 | DAO (0.51) | ALDH1A1KMT2AMAPTKDM4ECYP1A2 | |
| SCHEMBL3485414 | 0.67 | ALDH1A1 (1.00) | ALDH1A1DPYDMEN1KMT2AMAPT | |
| SCHEMBL28417123 | 0.67 | ADORA2B (0.41) | ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL28412210 | 0.67 | HPGD (0.36) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL28288685 | 0.67 | HPGD (0.36) | LMNAGAA | |
| SCHEMBL28412209 | 0.66 | TYMP (0.51) | ALDH1A1KDM4EGAA | |
| SCHEMBL28414535 | 0.66 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9597919 | 0.66 | TYMP (0.38) | ALDH1A1KDM4EGAA | |
| SCHEMBL28827211 | 0.65 | ATM (0.45) | ALDH1A1MEN1KMT2AMAPTTAAR1 | |
| SCHEMBL20393945 | 0.65 | DPYD (0.52) | ALDH1A1DPYDMAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102441170-A | Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs | ADHEREX TECHNOLOGIES INC | 2012-05-09 | — | — | CN | claimed |
| WO-2009100367-A2 | COMPOSITIONS COMPRISING TOPICAL DPD INHIBITORS AND METHODS OF USING SAME IN THE TREATMENT OF HAND-FOOT SYNDROME | ADHEREX TECHNOLOGIES INC. (CA) | 2009-08-13 | — | — | WO | claimed |
| US-20090196833-A1 | COMPOSITIONS COMPRISING TOPICAL DPD INHIBITORS AND METHODS OF USING SAME IN THE TREATMENT OF HAND-FOOT SYNDROME | ADHEREX TECHNOLOGIES INC. (CA) | 2009-08-06 | — | — | US | claimed |
| US-20080255168-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES, INC. (CA) | 2008-10-16 | — | — | US | claimed |
| CN-101068549-A | Methods of administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs | ADHEREX TECHNOLOGIES INC (CA) | 2007-11-07 | — | — | CN | claimed |
| EP-1827443-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | Adherex Technologies, Inc. (CA) | 2007-09-05 | — | — | EP | claimed |
| WO-2006060697-A9 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES INC (CA) | 2006-09-21 | — | — | WO | claimed |
| US-20060148753-A1 | Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs | ADHEREX TECHNOLOGIES, INC. (CA) | 2006-07-06 | — | — | US | claimed |
| WO-2006060697-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | ADHEREX TECHNOLOGIES, INC. (CA) | 2006-06-08 | — | — | WO | claimed |
| US-RE37623-E1 | PHENYLTHIO AND PHENYLSELENO PYRIMIDINE ANALOGS | el Kouni, Mahmoud H. | 2002-04-02 | — | — | US | claimed |
| EP-0725641-B1 | NOVEL INHIBITORS OF URIDINE PHOSPHORYLASE (UrdPase) AND DIHYDROURACIL DEHYDROGENASE (DHUDase) | EL KOUNI MAHMOUD H (US) | 2000-12-13 | — | — | EP | claimed |
| US-5721241-A | PYRIMIDINE COMPOUND USEFUL TO DISRUPT VIRAL, CANCER, FUNGAL, PARASITE OR BACTERIAL REPLICATION AND DIHYDROURACIL DEHYDROGENASE OR URIDINE PHOSPHORYLASE INHIBITORS | el Kouni, Mahmoud H. (US) | 1998-02-24 | — | — | US | claimed |
| EP-0725641-A4 | — | — | 1996-09-04 | — | — | EP | claimed |
| EP-0725641-A1 | NOVEL ENZYME INHIBITORS, THEIR SYNTHESIS, AND METHODS FOR USE | El Kouni, Mahmoud H. (US) | 1996-08-14 | — | — | EP | claimed |
| US-5476855-A | Pyrimidine analogs and nucleosides | el Kouni, Mahmoud H. (US) | 1995-12-19 | — | — | US | claimed |
| WO-1995012400-A1 | NOVEL ENZYME INHIBITORS, THEIR SYNTHESIS, AND METHODS FOR USE | UAB RESEARCH FOUNDATION (US) | 1995-05-11 | — | — | WO | claimed |
| US-20130184232-A1 | METHODS FOR ADMINISTERING DPD INHIBITORS IN COMBINATION WITH 5-FU AND 5-FU PRODRUGS | SPECTOR THOMAS (US) | 2013-07-18 | — | — | US | disclosed |
| US-8318756-B2 | Dihydropyrimidine dehydrogenase (DPD) inhibitors; 5-fluorouracil; anticancer | ADHEREX TECHNOLOGIES, INC. (CA) | 2012-11-27 | — | — | US | disclosed |
| US-5476855-A | Pyrimidine analogs and nucleosides | el Kouni, Mahmoud H. (US) | 1995-12-19 | — | — | US | disclosed |
| WO-1995012400-A1 | NOVEL ENZYME INHIBITORS, THEIR SYNTHESIS, AND METHODS FOR USE | UAB RESEARCH FOUNDATION (US) | 1995-05-11 | — | — | WO | disclosed |