Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tropisetron. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A known ✓ | P46098 | 9/20 | 1.00 |
| ▸ | HTR3E known ✓ | A5X5Y0 | 7/20 | 1.00 |
| ▸ | HTR3B known ✓ | O95264 | 7/20 | 1.00 |
| ▸ | HTR3D known ✓ | Q70Z44 | 7/20 | 1.00 |
| ▸ | HTR3C known ✓ | Q8WXA8 | 7/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | CHRNA7 | P36544 | 3/20 | 1.00 |
| ▸ | CHRNA1 | P02708 | 2/20 | 1.00 |
| ▸ | CHRNG | P07510 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CHRNB1 | P11230 | 2/20 | 1.00 |
| ▸ | CHRNB2 | P17787 | 2/20 | 1.00 |
| ▸ | CHRNA3 | P32297 | 2/20 | 1.00 |
| ▸ | CHRNA4 | P43681 | 2/20 | 1.00 |
| ▸ | CHRND | Q07001 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tropisetron SCHEMBL18297 | 1.00 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL18299 | 1.00 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL29405651 | 1.00 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL17766649 | 1.00 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL31061471 | 1.00 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL463128 | 1.00 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL29930627 | 1.00 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL6273985 | 0.99 | APEX1 (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL669358 | 0.99 | APEX1 (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL133873 | 0.99 | APEX1 (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11325904-B2 | Tropinol esters and related compounds to promote normal processing of APP | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2022-05-10 | — | — | US | disclosed |
| US-11325904-B2 | Tropinol esters and related compounds to promote normal processing of APP | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2022-05-10 | — | — | US | disclosed |
| US-9937163-B2 | Remedy for psychoneurotic diseases | NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY (JP) | 2018-04-10 | — | — | US | disclosed |
| US-20180072758-A1 | 5HT3 RECEPTOR ANTAGONISTS | TAKEDA CALIFORNIA, INC. | 2018-03-15 | — | — | US | disclosed |
| US-9695195-B2 | 5-HT3 receptor antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-07-04 | — | — | US | disclosed |
| US-9518034-B2 | Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2016-12-13 | — | — | US | disclosed |
| US-9518034-B2 | Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2016-12-13 | — | — | US | disclosed |
| US-20160185801-A1 | 5-HT3 RECEPTOR ANTAGONISTS | TAKEDA PHARMACEUTICAL (JP) | 2016-06-30 | — | — | US | disclosed |
| US-9303045-B2 | 5-HT3 receptor antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-04-05 | — | — | US | disclosed |
| US-20150291624-A1 | 5-HT3 RECEPTOR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-10-15 | — | — | US | disclosed |
| US-20150105552-A1 | SYNTHESIS OF CHIRAL ENAMINONES, THEIR DERIVATIVES, AND BIOACTIVITY STUDIES THEREOF | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2015-04-16 | — | — | US | disclosed |
| US-20140364451-A1 | TROPINOL ESTERS AND RELATED COMPOUNDS TO PROMOTE NORMAL PROCESSING OF APP | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364451-A1 | TROPINOL ESTERS AND RELATED COMPOUNDS TO PROMOTE NORMAL PROCESSING OF APP | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364451-A1 | TROPINOL ESTERS AND RELATED COMPOUNDS TO PROMOTE NORMAL PROCESSING OF APP | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140163062-A1 | REMEDY FOR PSYCHONEUROTIC DISEASES | NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY (JP) | 2014-06-12 | — | — | US | disclosed |
| US-20130324572-A1 | REMEDY FOR PSYCHONEUROTIC DISEASES | NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY (JP) | 2013-12-05 | — | — | US | disclosed |
| US-8470846-B2 | Administering tropisetron to prevent and treat Schizophrenia, Alzheimer's, Parkinson's, and Huntington's Diseases,Tourette's Syndrome and Attention deficit disorder; antidepressants, anxiolytic and antiepileptic agents | NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY (JP) | 2013-06-25 | — | — | US | disclosed |
| EP-1741430-B1 | REMEDY FOR PSYCHONEUROTIC DISEASES | UNIV CHIBA NAT UNIV CORP (JP) | 2009-07-15 | — | — | EP | disclosed |
| US-20080103166-A1 | Remedy For Psychoneurotic Diseases | NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY (JP) | 2008-05-01 | — | — | US | disclosed |
| EP-1741430-A1 | REMEDY FOR PSYCHONEUROTIC DISEASES | National University Corporation Chiba University (JP) | 2007-01-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185801-A1 | 5-HT3 RECEPTOR ANTAGONISTS | HTR3A, HTR5A, HTR3B | HTR3A 1/4885HTR3E 6/4885HTR3B 3/4885 |
| US-20150105552-A1 | SYNTHESIS OF CHIRAL ENAMINONES, THEIR DERIVATIVES, AND BIOACTIVITY STUDIES THEREOF | CYP51A1, LSS, PRMT7 | HTR3A 3621/4885HTR3E 4650/4885HTR3B 2966/4885 |
| US-20150291624-A1 | 5-HT3 RECEPTOR ANTAGONISTS | HTR3A, HTR5A, HTR3B | HTR3A 1/4885HTR3E 6/4885HTR3B 3/4885 |
| US-20140364451-A1 | TROPINOL ESTERS AND RELATED COMPOUNDS TO PROMOTE NORMAL PROCESSING OF APP | APP, BACE1, APBA1 | HTR3A 1217/4885HTR3E 1403/4885HTR3B 1494/4885 |
| US-20180072758-A1 | 5HT3 RECEPTOR ANTAGONISTS | HTR3A, HTR3B, HTR5A | HTR3A 1/4885HTR3E 6/4885HTR3B 2/4885 |
| US-11325904-B2 | Tropinol esters and related compounds to promote normal processing of APP | APP, BACE1, APBA1 | HTR3A 1217/4885HTR3E 1403/4885HTR3B 1494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.