Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.41 |
| ▸ | CTSL | P07711 | 6/20 | 0.41 |
| ▸ | CTSS | P25774 | 6/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.36 |
| ▸ | F10 | P00742 | 3/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3959334 | 0.95 | CTSL (0.38) | CTSKCTSLCTSSCTSBSIGMAR1 | |
| SCHEMBL3168819 | 0.92 | CTSK (0.42) | CTSKCTSLCTSSCTSBSIGMAR1 | |
| SCHEMBL3165918 | 0.92 | CTSK (0.42) | CTSKCTSLCTSSCTSBSIGMAR1 | |
| SCHEMBL3166608 | 0.90 | CTSS (0.47) | CTSKCTSLCTSSCTSBSIGMAR1 | |
| SCHEMBL3166033 | 0.90 | CTSK (0.41) | CTSKCTSLCTSSCTSBSIGMAR1 | |
| SCHEMBL3170053 | 0.90 | CTSL (0.38) | CTSKCTSLCTSSCTSBSIGMAR1 | |
| SCHEMBL3176722 | 0.90 | CTSK (0.43) | CTSKCTSLCTSSCTSBF10 | |
| SCHEMBL3174539 | 0.89 | CTSL (0.47) | CTSKCTSLCTSSCTSBSIGMAR1 | |
| SCHEMBL3170065 | 0.89 | CTSL (0.38) | CTSKCTSLCTSSCTSBSIGMAR1 | |
| SCHEMBL3165113 | 0.89 | CTSS (0.46) | CTSKCTSLCTSSCTSBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077841-A1 | NOVEL SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | Glaxo Group Limited (GB) | 2009-07-15 | — | — | EP | claimed |
| WO-2008052934-A1 | NOVEL SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-05-08 | — | — | WO | claimed |