Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31212623 | 0.84 | HIF1A (0.50) | HIF1ASMN1; SMN2CYP3A4CYP2C19LMNA | |
| SCHEMBL498294 | 0.84 | HIF1A (0.50) | HIF1ASMN1; SMN2CYP3A4CYP2C19LMNA | |
| SCHEMBL28140995 | 0.84 | HIF1A (0.50) | HIF1ASMN1; SMN2CYP3A4CYP2C19LMNA | |
| SCHEMBL17536667 | 0.82 | KMT2A (0.44) | SMN1; SMN2CYP3A4CYP2C19LMNAMEN1 | |
| SCHEMBL7151140 | 0.82 | KMT2A (0.44) | SMN1; SMN2CYP3A4CYP2C19LMNAMEN1 | |
| SCHEMBL5031234 | 0.80 | HIF1A (0.50) | HIF1ASMN1; SMN2CYP3A4CYP2C19LMNA | |
| SCHEMBL27945054 | 0.80 | HIF1A (0.50) | HIF1ASMN1; SMN2CYP3A4CYP2C19LMNA | |
| SCHEMBL1887926 | 0.80 | LMNA (0.44) | HIF1ASMN1; SMN2CYP3A4CYP2C19LMNA | |
| SCHEMBL9839841 | 0.79 | HIF1A (0.53) | HIF1ASMN1; SMN2CYP3A4CYP2C19LMNA | |
| SCHEMBL27305322 | 0.78 | HIF1A (0.49) | HIF1ASMN1; SMN2CYP3A4CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021354-A2 | N-TERMINALLY MODIFIED GLP-1 RECEPTOR MODULATORS | Brystol-Myers Squibb Company (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007140284-A2 | N-TERMINALLY MODIFIED GLP-1 RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-06 | — | — | WO | disclosed |