Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5031234 | 0.83 | HIF1A (0.50) | HIF1ASMN1; SMN2SLC6A2TAAR1CYP3A4 | |
| SCHEMBL31212623 | 0.83 | HIF1A (0.50) | HIF1ASMN1; SMN2SLC6A2TAAR1CYP3A4 | |
| SCHEMBL27945054 | 0.83 | HIF1A (0.50) | HIF1ASMN1; SMN2SLC6A2TAAR1CYP3A4 | |
| SCHEMBL28140995 | 0.83 | HIF1A (0.50) | HIF1ASMN1; SMN2SLC6A2TAAR1CYP3A4 | |
| SCHEMBL498294 | 0.83 | HIF1A (0.50) | HIF1ASMN1; SMN2SLC6A2TAAR1CYP3A4 | |
| SCHEMBL27305322 | 0.81 | HIF1A (0.49) | HIF1ASMN1; SMN2SLC6A2TAAR1CYP3A4 | |
| SCHEMBL3955413 | 0.79 | HIF1A (0.46) | HIF1ASMN1; SMN2SLC6A2TAAR1CYP3A4 | |
| SCHEMBL31132445 | 0.77 | HIF1A (0.49) | HIF1ASMN1; SMN2SLC6A2TAAR1CYP3A4 | |
| SCHEMBL1325186 | 0.77 | SMN1; SMN2 (0.57) | HIF1ASMN1; SMN2SLC6A2TAAR1CYP3A4 | |
| SCHEMBL1887926 | 0.76 | LMNA (0.44) | HIF1ASMN1; SMN2SLC6A2TAAR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991001724-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1991-02-21 | — | — | WO | claimed |