Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954326 | 0.81 | ALDH1A1 (0.39) | ALDH1A1S1PR5DRD2DRD3KEAP1 | |
| SCHEMBL28891925 | 0.81 | GNAO1 (0.48) | DRD2DRD3HSD17B10HRH3 | |
| SCHEMBL3947870 | 0.80 | ALDH1A1 (0.45) | ALDH1A1S1PR5HPGDCYP2D6PKM | |
| SCHEMBL3954975 | 0.80 | CYP1A2 (0.40) | ALDH1A1S1PR5DRD2DRD3KEAP1 | |
| SCHEMBL3957675 | 0.79 | ALDH1A1 (0.38) | ALDH1A1S1PR5DRD2DRD3KEAP1 | |
| SCHEMBL3950050 | 0.78 | ALDH1A1 (0.38) | ALDH1A1S1PR5DRD2DRD3KEAP1 | |
| SCHEMBL3951360 | 0.78 | ALDH1A1 (0.38) | ALDH1A1S1PR5DRD2DRD3KEAP1 | |
| SCHEMBL3954973 | 0.78 | ALDH1A1 (0.38) | ALDH1A1S1PR5DRD2DRD3KEAP1 | |
| SCHEMBL3956742 | 0.77 | ALDH1A1 (0.39) | ALDH1A1S1PR5DRD2DRD3KEAP1 | |
| SCHEMBL3955628 | 0.77 | ALDH1A1 (0.39) | ALDH1A1S1PR5DRD2DRD3KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |