Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 6/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.37 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28957069 | 0.95 | GNAO1 (0.50) | GNAO1ITGB3ITGA2BTPSAB1TPSD1 | |
| SCHEMBL28891866 | 0.90 | GNAO1 (0.43) | GNAO1ITGB3ITGA2BTPSAB1TPSD1 | |
| SCHEMBL28891924 | 0.83 | ITGB3 (0.49) | GNAO1ITGB3ITGA2BTPSAB1TPSD1 | |
| SCHEMBL3955633 | 0.81 | ALDH1A1 (0.39) | HSD17B10DRD2DRD3HRH3 | |
| SCHEMBL9675410 | 0.80 | GNAO1 (0.57) | GNAO1ITGB3ITGA2BTPSAB1TPSD1 | |
| SCHEMBL28891890 | 0.80 | CACNA2D1 (0.46) | GNAO1HSD17B10DRD2 | |
| SCHEMBL28891983 | 0.79 | GNAO1 (0.44) | GNAO1ITGB3ITGA2BTPSAB1TPSD1 | |
| SCHEMBL5848080 | 0.79 | GNAO1 (0.56) | GNAO1ITGB3ITGA2BTPSAB1TPSD1 | |
| SCHEMBL7128349 | 0.79 | GNAO1 (0.56) | GNAO1ITGB3ITGA2BTPSAB1TPSD1 | |
| SCHEMBL7122133 | 0.78 | GNAO1 (0.54) | GNAO1ITGB3ITGA2BTPSAB1TPSD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022223033-A1 | SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115232111-A | SOS1 degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2022-10-25 | — | — | CN | disclosed |