Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 7/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5362273 | 0.87 | — | — | |
| SCHEMBL3955905 | 0.86 | TSHR (0.48) | ALDH1A1TSHRDRD2SIGMAR1FAAH | |
| SCHEMBL2552869 | 0.86 | ALDH1A1 (0.38) | ALDH1A1TSHRSIGMAR1MEN1KMT2A | |
| SCHEMBL2561862 | 0.83 | SIGMAR1 (0.46) | ALDH1A1TSHRDRD2SIGMAR1MEN1 | |
| SCHEMBL13464060 | 0.81 | CXCR4 (0.46) | SIGMAR1POLBMEN1KMT2A | |
| SCHEMBL2561626 | 0.81 | DRD2 (0.39) | DRD2SIGMAR1POLBGNAI3GNAO1 | |
| SCHEMBL7289625 | 0.79 | TSHR (0.56) | ALDH1A1TSHRDRD2SIGMAR1FAAH | |
| SCHEMBL1046369 | 0.79 | DRD2 (0.52) | DRD2SIGMAR1GNAI3GNAO1GNAI1 | |
| SCHEMBL19546253 | 0.79 | DRD2 (0.52) | DRD2SIGMAR1GNAI3GNAO1GNAI1 | |
| SCHEMBL384210 | 0.79 | DRD2 (0.52) | DRD2SIGMAR1GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |