Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.37 |
| ▸ | THRA | P10827 | 5/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSPO | P30536 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3221169 | 0.95 | THRB (0.39) | THRBESR1RORCUSP2LMNA | |
| SCHEMBL3225821 | 0.93 | THRB (0.40) | THRBTHRARORCUSP2LMNA | |
| SCHEMBL3224353 | 0.88 | THRB (0.41) | THRBESR1RORCUSP2LMNA | |
| SCHEMBL3226580 | 0.86 | THRB (0.42) | THRBTHRARORCUSP2LMNA | |
| SCHEMBL3225634 | 0.86 | ALDH1A1 (0.39) | THRBRORCUSP2LMNAPPARG | |
| SCHEMBL3708448 | 0.84 | THRB (0.45) | THRBTHRAESR1RORCUSP2 | |
| SCHEMBL3701809 | 0.83 | THRB (0.40) | THRBESR1RORCUSP2LMNA | |
| SCHEMBL3793749 | 0.82 | THRB (0.41) | THRBTHRARORCUSP2LMNA | |
| SCHEMBL3227152 | 0.79 | POLB (0.46) | LMNAPPARGALDH1A1TSHRMAPT | |
| SCHEMBL3793748 | 0.79 | THRB (0.43) | THRBTHRARORCUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079678-A2 | SELECTIVE TR-BETA 1 AGONIST | Cadila Healthcare Limited (IN) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008062469-A2 | SELECTIVE TR-BETA 1 AGONIST | CADILA HEALTHCARE LIMITED (IN) | 2008-05-29 | — | — | WO | disclosed |