Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CCL2 | P13500 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29574289 | 1.00 | HTR2A (0.39) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Hydrochloric Acid SCHEMBL3670932 | 0.98 | HTR2A (0.38) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Ethylene SCHEMBL4978169 | 0.96 | HTR2A (0.36) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Fluoride Ion SCHEMBL7637223 | 0.95 | HTR2A (0.39) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Bromide SCHEMBL5368508 | 0.95 | HTR2A (0.43) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Bromide SCHEMBL31427621 | 0.95 | HTR2A (0.43) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| SCHEMBL4576586 | 0.95 | HTR2A (0.39) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| SCHEMBL7032645 | 0.91 | HTR2A (0.36) | HTR2AHTR6SIGMAR1KDM4ECYP2D6 | |
| Hydrochloric Acid SCHEMBL7644480 | 0.90 | HTR6 (0.33) | HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL30449732 | 0.86 | HTR6 (0.33) | HTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 331 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186782-B2 | Hydrogenation catalyst composition and process for hydrogenation of conjugated diene polymer | TSRC CORPORATION (TW) | 2007-03-06 | — | — | US | claimed |
| US-20060041079-A1 | Hydrogenation catalyst composition and process for hydrogenation of conjugated diene polymer | TSRC CORPORATION | 2006-02-23 | — | — | US | claimed |
| US-6982236-B2 | Process to polymerize olefins | UNIVATION TECHNOLOGIES, LLC (US) | 2006-01-03 | — | — | US | claimed |
| US-6897273-B2 | Catalyst composition, method of polymerization and polymer therefrom | UNIVATION TECHNOLOGIES, LLC (US) | 2005-05-24 | — | — | US | claimed |
| US-6881797-B2 | Process for hydrogenation of conjugated diene polymer | TSRC CORPORATION (TW) | 2005-04-19 | — | — | US | claimed |
| US-20040082727-A1 | Process for hydrogenation of conjugated diene polymer | TSRC CORPORATION (CN) | 2004-04-29 | — | — | US | claimed |
| US-6656866-B2 | Metallocene and non-metallocene, homogeneous catalysts, particularly for use in the economical gas and slurry phase processes; spray dried olefin polymerization catalysts | UNIVATION TECHNOLOGIES, LLC | 2003-12-02 | — | — | US | claimed |
| US-20030207762-A9 | CATALYST PREPARATION METHOD | UNIVATION TECHNOLOGIES, LLC | 2003-11-06 | — | — | US | claimed |
| US-20020119890-A1 | Catalyst preparation method | WENZEL TIMOTHY T (US) | 2002-08-29 | — | — | US | claimed |
| US-20020103310-A1 | Catalyst composition, method of polymerization and polymer therefrom | UNIVATION TECHNOLOGIES, LLC | 2002-08-01 | — | — | US | claimed |
| US-6143844-A | POLYMERIZING 1-OLEFINS BY CONTACING SLURRY OR GAS PHASE IN REACTORS WITH HETEROGENOUS CATALYST MADE BY CHEMISORBING IN A REACTION CHAMBER VAPORIZED METALLOCENE ONTO AN INORGANIC SUPPORT AND REMOVING UNREACTED METALLOCENE | BOREALIS A/S (DK) | 2000-11-07 | — | — | US | claimed |
| EP-0731729-B1 | METHOD FOR PREPARING A CATALYST FOR OLEFIN POLYMERIZATION | BOREALIS AS (DK) | 2000-03-01 | — | — | EP | claimed |
| US-5925717-A | SELECTIVE HYDROGENATION OF POLYMERS WITH TITANIUM CATALYSTS WITH INDENE COMPOUND LIGANDS | SHELL OIL COMPANY (US) | 1999-07-20 | — | — | US | claimed |
| US-5767032-A | TREATING A SOLID INORGANIC SUPPORT WITH A VAPORIZED METALLOCENE; COORDINATION CATALYSTS; REGULATION OF CATALYST ACTIVITY TO REGULATE POLYMER MOLECULAR WEIGHT AND MOLECULAR WEIGHT DISTRIBUTION | BOREALIS A/S (DK) | 1998-06-16 | — | — | US | claimed |
| EP-0795564-A1 | Process for hydrogenation of conjugated diene polymers and catalyst compositions suitable for use therein | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1997-09-17 | — | — | EP | claimed |
| EP-0731729-A1 | CATALYST FOR OLEFIN POLYMERIZATION AND A METHOD FOR THE MANUFACTURE THEREOF | BOREALIS A/S (DK) | 1996-09-18 | — | — | EP | claimed |
| WO-1995015216-A1 | CATALYST FOR OLEFIN POLYMERIZATION AND A METHOD FOR THE MANUFACTURE THEREOF | BOREALIS A/S (DK) | 1995-06-08 | — | — | WO | claimed |
| EP-0412750-B1 | Production of alpha-olefin polymers | MITSUBISHI PETROCHEMICAL CO (JP) | 1995-02-15 | — | — | EP | claimed |
| US-5104838-A | Titanium-containing solid catalyst component | MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) | 1992-04-14 | — | — | US | claimed |
| EP-0412750-A2 | Production of alpha-olefin polymers | MITSUBISHI CHEMICAL CORPORATION (JP) | 1991-02-13 | — | — | EP | claimed |