Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 5/20 | 0.36 |
| ▸ | CTSS | P25774 | 3/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3013440 | 0.92 | MEN1 (0.49) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL12475162 | 0.87 | MEN1 (0.49) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL30299043 | 0.86 | MAOA (0.53) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL13960156 | 0.85 | MEN1 (0.46) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL16379307 | 0.85 | MEN1 (0.46) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL570033 | 0.83 | MEN1 (0.50) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL13959822 | 0.83 | MEN1 (0.54) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL18614971 | 0.82 | MEN1 (0.54) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL3025341 | 0.82 | MAOA (0.44) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL1760969 | 0.80 | MEN1 (0.59) | MEN1GAAKMT2ATDP1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866291-B1 | ANTIBACTERIAL AMIDE MACROCYCLES VI | AICURIS GMBH & CO KG (DE) | 2009-07-15 | — | — | EP | disclosed |
| EP-1866291-A1 | ANTIBACTERIAL AMIDE MACROCYCLES VI | AiCuris GmbH & Co. KG (DE) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006103009-A1 | ANTIBACTERIAL AMIDE MACROCYCLES VI | AICURIS GMBH & CO. KG (DE) | 2006-10-05 | — | — | WO | disclosed |