Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PTPRA | P18433 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17350556 | 0.84 | SMN1; SMN2 (0.49) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL27666794 | 0.76 | HRH1 (0.40) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL12204158 | 0.76 | TRPM8 (0.60) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL30753585 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTALDH1A1CYP1A2TSHR | |
| SCHEMBL12320823 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTALDH1A1CYP1A2TSHR | |
| SCHEMBL3938108 | 0.76 | KDM4E (0.41) | TRPM8TDP1ALDH1A1TSHRKMT2A | |
| SCHEMBL29088338 | 0.75 | LMNA (0.49) | TRPM8SMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL4015323 | 0.74 | L3MBTL1 (0.41) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL19889221 | 0.74 | TDP1 (0.57) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 | |
| SCHEMBL12313339 | 0.74 | NTRK1 (0.51) | TRPM8SMN1; SMN2MAPTLIN28ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713515-A4 | TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES, AND METHODS OF USE THEREOF | MOLECULAR INSIGHT PHARM INC (US) | 2009-07-22 | — | — | EP | disclosed |
| EP-1713515-A1 | TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES, AND METHODS OF USE THEREOF | Molecular Insight Pharmaceuticals, Inc. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005079865-A1 | TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES, AND METHODS OF USE THEREOF | MOLECULAR INSIGHT PHARMACEUTICALS (US) | 2005-09-01 | — | — | WO | disclosed |