Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3958263 | 0.85 | GAA (0.47) | GAAALDH1A1CYP3A4PDE4AADRA2B | |
| SCHEMBL27183403 | 0.82 | ALOX15 (0.67) | GAAALOX15ALOX12LMNACYP3A4 | |
| SCHEMBL11584588 | 0.78 | ALDH1A1 (0.50) | GAAALOX15ALOX12ALDH1A1LMNA | |
| SCHEMBL14276990 | 0.76 | SKP2 (0.45) | ALDH1A1CYP3A4TDP1SIGMAR1NR3C2 | |
| Bromide SCHEMBL6837017 | 0.76 | GAA (0.56) | GAAALDH1A1LMNACYP3A4LDHA | |
| SCHEMBL27205449 | 0.76 | GAA (0.65) | GAA | |
| SCHEMBL9069704 | 0.74 | ESR1 (0.61) | SIGMAR1 | |
| SCHEMBL4603238 | 0.74 | MEN1 (0.59) | ALDH1A1LDHASIGMAR1KMT2AMEN1 | |
| SCHEMBL4603241 | 0.74 | MEN1 (0.59) | ALDH1A1LDHASIGMAR1KMT2AMEN1 | |
| SCHEMBL8732205 | 0.73 | TAAR1 (0.52) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076497-A1 | AMINOMETHYL-4-IMIDAZOLES | F. Hoffmann-Roche AG (CH) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008046757-A1 | AMINOMETHYL-4-IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |