Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 4/20 | 0.33 |
| ▸ | JUN | P05412 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL3958704 | 1.00 | DRD2 (0.36) | DRD2HTR1AHTR2ADRD4KDM4E | |
| SCHEMBL3965962 | 0.98 | DRD2 (0.37) | DRD2HTR1AHTR2ADRD4KDM4E | |
| SCHEMBL4206216 | 0.98 | DRD2 (0.37) | DRD2HTR1AHTR2ADRD4KDM4E | |
| SCHEMBL3959690 | 0.87 | DRD2 (0.37) | DRD2HTR1AHTR2ADRD4KDM4E | |
| SCHEMBL3958935 | 0.87 | DRD2 (0.37) | DRD2HTR1AHTR2ADRD4KDM4E | |
| Oxalic Acid SCHEMBL3964740 | 0.87 | HTR7 (0.42) | DRD2HTR1AHTR2ADRD4KDM4E | |
| Oxalic Acid SCHEMBL3964749 | 0.87 | HTR7 (0.42) | DRD2HTR1AHTR2ADRD4KDM4E | |
| Oxalic Acid SCHEMBL27718856 | 0.87 | HTR7 (0.42) | DRD2HTR1AHTR2ADRD4KDM4E | |
| Hydrochloric Acid SCHEMBL3957821 | 0.87 | DRD2 (0.36) | DRD2HTR1AHTR2ADRD4KDM4E | |
| Hydrochloric Acid SCHEMBL3957825 | 0.87 | DRD2 (0.36) | DRD2HTR1AHTR2ADRD4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544685-B2 | 2,3-dihydroindole compounds | H. LUNDBECK A/S (DK) | 2009-06-09 | — | — | US | disclosed |
| US-20070043058-A1 | Novel 2,3-dihydroindole compounds | H. LUNDBECK A/S (DK) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043058-A1 | Novel 2,3-dihydroindole compounds | HTR2C, HTR2A, HTR5A | DRD2 24/4885HTR1A 4/4885HTR2A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.