Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 3/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27293534 | 0.74 | PKM (0.35) | MAPTNPC1MAPK1RAB9ACYP1A2 | |
| SCHEMBL4213317 | 0.74 | MMP13 (0.33) | MAPTMAPK1CYP1A2ALDH1A1CYP2D6 | |
| SCHEMBL8342993 | 0.67 | ALDH1A1 (0.44) | MAPTCYP1A2CYP2C9ALDH1A1POLB | |
| SCHEMBL28286529 | 0.67 | MAPT (0.37) | MAPTRAB9ACYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL4417473 | 0.67 | GRIN2D (0.41) | MAPTALDH1A1 | |
| SCHEMBL6036197 | 0.67 | ALDH1A1 (0.33) | MAPTNPC1MAPK1RAB9AALDH1A1 | |
| SCHEMBL4235814 | 0.67 | ALDH1A1 (0.37) | MAPTMAPK1ALDH1A1POLB | |
| SCHEMBL13909523 | 0.65 | MAPT (0.36) | MAPTNPC1MAPK1RAB9ACYP1A2 | |
| SCHEMBL20640620 | 0.65 | MAPT (0.51) | MAPTNPC1MAPK1RAB9ACYP1A2 | |
| SCHEMBL5709534 | 0.64 | ALDH1A1 (0.38) | MAPTMAPK1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009033165-A1 | HYPOXIA ACTIVATED PRODRUGS OF BIS-ALKYLATING AGENTS | THRESHOLD PHARMACEUTICALS, INC. (US) | 2009-03-12 | — | — | WO | disclosed |