Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3963736 | 0.84 | CYP1A2 (0.55) | CYP1A2CYP3A4CYP2D6CYP2C19HDAC1 | |
| SCHEMBL4232031 | 0.77 | TDP1 (0.51) | CYP1A2CYP3A4CYP2D6CYP2C19HDAC1 | |
| SCHEMBL27614794 | 0.76 | CYP1A2 (0.58) | CYP1A2CYP3A4CYP2D6CYP2C19HDAC1 | |
| SCHEMBL3959541 | 0.75 | CASR (0.46) | KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14537621 | 0.75 | CASR (0.46) | KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5947765 | 0.74 | CYP1A2 (0.61) | CYP1A2CYP3A4CYP2D6CYP2C19HDAC1 | |
| SCHEMBL3958999 | 0.74 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2D6CYP2C19HDAC1 | |
| SCHEMBL3878291 | 0.73 | CYP1A2 (0.63) | CYP1A2CYP3A4CYP2D6CYP2C19HDAC1 | |
| SCHEMBL5947247 | 0.72 | CYP1A2 (0.58) | CYP1A2CYP3A4CYP2D6CYP2C19HDAC1 | |
| SCHEMBL228959 | 0.72 | KIF18A (0.57) | CYP3A4CYP2C19HTR6ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079525-A1 | CALCIUM RECEPTOR MODULATING AGENTS | Amgen Inc. (US) | 2009-07-22 | — | — | EP | claimed |
| WO-2008057282-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2008-05-15 | — | — | WO | claimed |
| EP-2079525-A1 | CALCIUM RECEPTOR MODULATING AGENTS | Amgen Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008057282-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2008-05-15 | — | — | WO | disclosed |