Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 1.00 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29449723 | 1.00 | NOTUM (1.00) | NOTUMHSD17B3TSHRALDH1A1HPGD | |
| SCHEMBL29510859 | 0.89 | NOTUM (1.00) | NOTUMHSD17B3TSHRALDH1A1HPGD | |
| SCHEMBL709869 | 0.89 | NOTUM (1.00) | NOTUMHSD17B3TSHRALDH1A1HPGD | |
| SCHEMBL5423105 | 0.87 | NOTUM (0.90) | NOTUMHSD17B3TSHRALDH1A1HPGD | |
| Indoline SCHEMBL17479574 | 0.85 | NOTUM (0.72) | NOTUMHSD17B3TSHRALDH1A1HPGD | |
| SCHEMBL29804966 | 0.84 | NOTUM (0.72) | NOTUMTSHRALDH1A1HPGDLMNA | |
| SCHEMBL17117378 | 0.84 | NOTUM (0.72) | NOTUMTSHRALDH1A1HPGDLMNA | |
| SCHEMBL5492978 | 0.84 | SMN1; SMN2 (0.79) | NOTUMTSHRALDH1A1HPGDLMNA | |
| SCHEMBL19240154 | 0.83 | HSD17B3 (1.00) | NOTUMHSD17B3TSHRALDH1A1LMNA | |
| SCHEMBL789554 | 0.82 | ALDH1A1 (0.71) | NOTUMTSHRALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 627 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250388599-A1 | TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2025-12-25 | — | — | US | claimed |
| CN-119735600-A | 3-Ureido substituted thieno [2,3-b ] pyridine compound and preparation method and application thereof | 华东师范大学 | 2025-04-01 | — | — | CN | claimed |
| CN-117105898-A | Osthole 7-bit derivative and preparation method and application thereof | 遵义医科大学 | 2023-11-24 | — | — | CN | claimed |
| CN-116515275-A | Chopped glass fiber plastic alloy and preparation method thereof | 安徽捷云新材料科技有限公司 | 2023-08-01 | — | — | CN | claimed |
| CN-115353478-A | Preparation method of indole compound | 南京工业大学 | 2022-11-18 | — | — | CN | claimed |
| US-20220348593-A1 | TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. | 2022-11-03 | — | — | US | claimed |
| CN-114853642-A | Synthesis method for directly alkylating benzyl position of aromatic compound | 西湖大学 | 2022-08-05 | — | — | CN | claimed |
| CN-114014793-A | 5-substituted indoline derivative or salt thereof, preparation method and application thereof, and preparation method of silodosin | 安徽美致诚药业有限公司 | 2022-02-08 | — | — | CN | claimed |
| EP-3174932-B1 | CURE ACCELERATORS FOR ANAEROBIC CURABLE COMPOSITIONS | Henkel IP & Holding GmbH (DE) | 2021-06-09 | — | — | EP | claimed |
| CN-108558730-B | Synthetic method of 3- (3-oxoalkyl) substituted N-acetyl indoline compound | 江苏理工学院 | 2020-07-28 | — | — | CN | claimed |
| US-20120171199-A1 | TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | NOVOGEN LIMITED (AU) | 2012-07-05 | — | — | US | claimed |
| WO-2012082633-A1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2012-06-21 | — | — | WO | claimed |
| US-20120157444-A1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2012-06-21 | — | — | US | claimed |
| WO-2011137089-A1 | ACTIVATORS OF HUMAN PYRUVATE KINASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-11-03 | — | — | WO | claimed |
| US-20100233164-A1 | COMBINATIONS OF PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF HEMATOPOIETIC MALIGNANCIES | GENENTECH, INC. | 2010-09-16 | — | — | US | claimed |
| US-20090098135-A1 | COMBINATIONS OF PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND CHEMOTHERAPEUTIC AGENTS, AND METHODS OF USE | GENENTECH, INC. | 2009-04-16 | — | — | US | claimed |
| US-20080058525-A1 | NOVEL DYE COMPLEXES AND USE THEREOF IN IMAGING MEMBERS AND METHODS | ZINK IMAGING, LLC | 2008-03-06 | — | — | US | claimed |
| WO-2004078874-A2 | NOVEL DYE COMPLEXES AND USE THEREOF IN IMAGING MEMBERS AND METHODS | POLAROID CORPORATION (US) | 2004-09-16 | — | — | WO | claimed |
| US-20040171817-A1 | Novel dye complexes and use thereof in imaging members and methods | ZINK HOLDINGS LLC | 2004-09-02 | — | — | US | claimed |
| EP-0192492-B1 | PEPTIDES CONTAINING AN ALIPHATIC-AROMATIC KETONE SIDE CHAIN | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1992-01-02 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090098135-A1 | COMBINATIONS OF PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND CHEMOTHERAPEUTIC AGENTS, AND METHODS OF USE | PIK3CA, PIK3CD, AKT3 | NOTUM 3516/4885HSD17B3 776/4885TSHR 3750/4885 |
| US-20100233164-A1 | COMBINATIONS OF PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF HEMATOPOIETIC MALIGNANCIES | PIK3CA, PIK3CD, MCL1 | NOTUM 4008/4885HSD17B3 785/4885TSHR 4346/4885 |
| US-20120171199-A1 | TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | PIK3CA, PIK3CD, MTOR | NOTUM 2550/4885HSD17B3 1109/4885TSHR 3238/4885 |
| US-20220348593-A1 | TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | PIK3CA, PIK3CD, MTOR | NOTUM 2550/4885HSD17B3 1109/4885TSHR 3238/4885 |
| US-20080058525-A1 | NOVEL DYE COMPLEXES AND USE THEREOF IN IMAGING MEMBERS AND METHODS | DBI, HSPE1, ABCB7 | NOTUM 2148/4885HSD17B3 1621/4885TSHR 4584/4885 |
| US-20120157444-A1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | CXCR2, CCR2, CX3CR1 | NOTUM 4390/4885HSD17B3 3160/4885TSHR 901/4885 |
| US-20250388599-A1 | TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | PIK3C2B, PIK3C2A, PIK3R1 | NOTUM 4629/4885HSD17B3 1116/4885TSHR 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.