Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.42 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.42 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.42 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.42 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17754489 | 0.82 | APP (0.49) | APPPDGFRBPDGFRAHSD17B1HSD17B2 | |
| SCHEMBL14849707 | 0.81 | APP (0.52) | APPPDGFRBPDGFRACYP2E1CYP3A4 | |
| SCHEMBL5645611 | 0.79 | APP (0.50) | APPPDGFRBPDGFRACYP2E1CYP3A4 | |
| SCHEMBL14871942 | 0.79 | APP (0.46) | APPPDGFRBPDGFRACYP2E1CYP3A4 | |
| SCHEMBL10471434 | 0.78 | APP (0.53) | APPPDGFRBPDGFRACYP2E1CYP3A4 | |
| SCHEMBL14770213 | 0.77 | HDAC1 (0.50) | APPALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL3199986 | 0.77 | HSD17B1 (0.42) | APPCYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL11522028 | 0.77 | APP (0.83) | APPCYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL498650 | 0.75 | HSD17B1 (0.65) | APPCYP2E1CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL27898247 | 0.75 | CYP1A2 (0.51) | CYP3A4CYP2C9HSD17B1HSD17B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
| EP-1367111-B1 | PHOTOCHROMIC MATERIAL | JAPAN SCIENCE & TECH AGENCY (JP) | 2009-07-22 | — | — | EP | disclosed |
| EP-1367111-B1 | PHOTOCHROMIC MATERIAL | JAPAN SCIENCE & TECH AGENCY (JP) | 2009-07-22 | — | — | EP | disclosed |
| US-7057054-B2 | Hexafluorocyclopentene di-substituted with an alkoxy- and aryl-substituted furan and/or thiophene; e.g., 1,2-bis(2-methoxy-5-phenyl-3-thienyl)hexafluorocyclopentene; nonfading | JAPAN SCIENCE AND TECHNOLOGY CORPORATION (JP) | 2006-06-06 | — | — | US | disclosed |
| US-20040049040-A1 | Pohtochromic material | JAPAN SCIENCE AND TECHNOLOGY CORPORATION | 2004-03-11 | — | — | US | disclosed |
| EP-1367111-A1 | PHOTOCHROMIC MATERIAL | Japan Science and Technology Corporation (JP) | 2003-12-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040049040-A1 | Pohtochromic material | CRY1, CRY2, PAH | APP 2683/4885PDGFRB 4370/4885PDGFRA 4092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.