Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.42 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3959574 | 0.86 | CYP1A2 (0.46) | NPC1POLBMEN1MAPTKMT2A | |
| SCHEMBL3964180 | 0.79 | NPC1 (0.42) | NPC1MAPTRAB9ATSHRHTT | |
| SCHEMBL3966975 | 0.79 | HTT (0.39) | CDK2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL2092068 | 0.75 | NPC1 (0.51) | CCNE1CDK2CDK5NPC1POLB | |
| SCHEMBL3966365 | 0.75 | TGM2 (0.43) | POLBEPHX2TRPV1 | |
| SCHEMBL3956362 | 0.75 | EPHX2 (0.41) | NPC1MEN1KMT2AEPHX2RAB9A | |
| SCHEMBL3966081 | 0.75 | KDM4E (0.47) | MEN1KMT2AALDH1A1KDM4ECYP2C19 | |
| SCHEMBL2089305 | 0.75 | NPC1 (0.50) | CCNE1CDK2CDK5NPC1POLB | |
| SCHEMBL14448258 | 0.71 | HTR3A (0.58) | CCNE1CDK2CDK5NPC1POLB | |
| Hydrochloric Acid SCHEMBL5467852 | 0.70 | HTR3A (0.57) | CCNE1CDK2CDK5NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069346-A1 | ACETAMIDE AND CARBOXAMIDE DERIVATIVES OF AZAADAMANTANE AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008118743-A1 | ACETAMIDE AND CARBOXAMIDE DERIVATIVES OF AZAADAMANTANE AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2008-10-02 | — | — | WO | disclosed |