Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4058857 | 0.84 | EGLN1 (0.57) | EGLN1EGLN3 | |
| SCHEMBL2057951 | 0.72 | NPC1 (0.43) | EGLN1NPC1RAB9AKMT2AEGLN3 | |
| SCHEMBL2399702 | 0.70 | MEN1 (0.77) | EGFRSRCEGLN1HIF1AMEN1 | |
| SCHEMBL4061386 | 0.70 | EGLN1 (0.60) | EGLN1EGLN3 | |
| SCHEMBL4065499 | 0.68 | RPA1 (0.58) | EGFRSRCEGLN1MEN1NPC1 | |
| SCHEMBL2385170 | 0.68 | EGLN1 (0.59) | EGFRSRCEGLN1HIF1AMEN1 | |
| SCHEMBL2882557 | 0.68 | EGLN1 (0.58) | EGFRSRCEGLN1 | |
| SCHEMBL13225926 | 0.67 | EGFR (0.65) | EGFRSRCEGLN1HIF1AMEN1 | |
| SCHEMBL1585620 | 0.67 | EGLN1 (0.48) | EGFRSRCEGLN1HIF1AMEN1 | |
| SCHEMBL2381250 | 0.67 | EGLN1 (0.61) | EGLN1HIF1AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009039321-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | claimed |
| WO-2009039321-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009039321-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | disclosed |