Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.40 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24784372 | 0.86 | NPC1 (0.49) | NPC1RAB9AKDM4EALDH1A1GAA | |
| SCHEMBL2057284 | 0.80 | KDM4E (0.47) | NPC1RAB9AEGLN1RXFP1KDM4E | |
| SCHEMBL24784343 | 0.77 | THRB (0.71) | KDM4EHSD17B10POLBTHRBALDH1A1 | |
| SCHEMBL24784345 | 0.77 | THRB (0.71) | KDM4EHSD17B10POLBTHRBALDH1A1 | |
| SCHEMBL24784344 | 0.77 | THRB (0.71) | KDM4EHSD17B10POLBTHRBALDH1A1 | |
| SCHEMBL2057744 | 0.75 | EGLN1 (0.44) | EGLN1 | |
| SCHEMBL4056990 | 0.74 | EGLN1 (0.47) | EGLN1EGLN3FTO | |
| SCHEMBL2058021 | 0.74 | EGLN1 (0.39) | EGLN1EGLN3THRBSMN1; SMN2 | |
| SCHEMBL24784374 | 0.73 | MAPK1 (0.60) | NPC1RAB9ARXFP1KDM4ENPSR1 | |
| SCHEMBL3961179 | 0.72 | EGFR (0.49) | NPC1RAB9AEGLN1EGLN3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160227-A1 | Prolyl Hydroxylase Inhibitors | GLAXOSMITHKLINE LLC | 2011-06-30 | — | — | US | claimed |
| US-20110160227-A1 | Prolyl Hydroxylase Inhibitors | GLAXOSMITHKLINE LLC | 2011-06-30 | — | — | US | disclosed |
| US-20110160227-A1 | Prolyl Hydroxylase Inhibitors | GLAXOSMITHKLINE LLC | 2011-06-30 | — | — | US | disclosed |
| US-20110160227-A1 | Prolyl Hydroxylase Inhibitors | GLAXOSMITHKLINE LLC | 2011-06-30 | — | — | US | disclosed |
| WO-2010022307-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160227-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN2, EGLN3 | NPC1 1595/4885RAB9A 4158/4885EGLN1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.