Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061386 | 0.73 | EGLN1 (0.60) | SMN1; SMN2EGLN1EGLN3 | |
| SCHEMBL13908269 | 0.71 | EGLN1 (0.43) | EGLN1EGLN3 | |
| SCHEMBL4737701 | 0.69 | ERCC1 (0.48) | SMN1; SMN2ALDH1A1LMNAKDM4EHSD17B10 | |
| SCHEMBL2153297 | 0.69 | SMN1; SMN2 (0.93) | RPA1SMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL4075882 | 0.68 | EGLN1 (0.48) | EGLN1EGLN3BBOX1ASPHKDM8 | |
| SCHEMBL3961179 | 0.68 | EGFR (0.49) | RAB9ANPC1EGLN1EGFRSRC | |
| SCHEMBL1585697 | 0.68 | EGLN1 (0.48) | EGLN1KDM4CEGFRSRCEGLN3 | |
| SCHEMBL1585620 | 0.68 | EGLN1 (0.48) | RAB9ANPC1EGLN1EGFRSRC | |
| SCHEMBL30935867 | 0.67 | RPA1 (0.57) | RPA1SMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL15180301 | 0.67 | RPA1 (0.57) | RPA1SMN1; SMN2ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009039322-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | claimed |
| WO-2009039322-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-03-26 | — | — | WO | disclosed |