Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5151745 | 0.75 | NPC1 (0.32) | NPC1RAB9A | |
| SCHEMBL13586875 | 0.73 | CES2 (0.46) | CES2CES1NPC1RAB9APOLB | |
| Bromide SCHEMBL7429002 | 0.73 | NPC1 (0.32) | NPC1RAB9A | |
| SCHEMBL1258944 | 0.73 | CES2 (0.74) | CES2CES1NPC1RAB9APOLB | |
| SCHEMBL697332 | 0.73 | NPC1 (0.54) | CES2CES1NPC1RAB9APARP1 | |
| SCHEMBL8490277 | 0.72 | S1PR2 (0.38) | NPC1RAB9APOLBKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL27733562 | 0.71 | CES2 (0.71) | CES2CES1POLBPARP1KMT2A | |
| SCHEMBL2705684 | 0.71 | CES2 (0.71) | CES2CES1POLBPARP1KMT2A | |
| SCHEMBL806857 | 0.71 | KCNK3 (0.64) | CES2CES1NPC1RAB9APOLB | |
| SCHEMBL15647249 | 0.70 | KMT2A (0.50) | CES2CES1NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7626031-B2 | 5-[(1-Ethylpiperidin-4-yl)amino]-3-[(3-fluorophenyl)(1H-imidazol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one; antiproliferative agents; modulating cell differentiation,migration, and chemoinvasion; endothelial growth factor-modulated diseases; antiarthritic agents; graft versus host diseases | SYMPHONY EVOLUTION, INC. (US) | 2009-12-01 | — | — | US | disclosed |
| EP-1581309-A4 | KINASE MODULATORS | EXELIXIS INC (US) | 2009-07-29 | — | — | EP | disclosed |
| US-20060122171-A1 | Kinase modulators | SYMPHONY EVOLUTION, INC. | 2006-06-08 | — | — | US | disclosed |
| EP-1581309-A2 | KINASE MODULATORS | Exelixis, Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050681-A2 | KINASE MODULATORS | EXELIXIS, INC. (US) | 2004-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122171-A1 | Kinase modulators | FLT1, KDR, FLT4 | CES2 2989/4885CES1 3014/4885NPC1 4191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.