Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 8/20 | 0.42 |
| ▸ | HTR2A known ✓ | P28223 | 7/20 | 0.42 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 7/20 | 0.42 |
| ▸ | PNMT | P11086 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14091674 | 0.91 | HTR2C (0.50) | HTR2CHTR2AHTR2BPNMTADRA2A | |
| Succinic Acid SCHEMBL3963011 | 0.87 | TBXAS1 (0.45) | HTR2CHTR2AHTR2BTBXAS1 | |
| Succinic Acid SCHEMBL3969905 | 0.81 | HTR2A (0.39) | HTR2CHTR2AHTR2BPNMTADRA2A | |
| Succinic Acid SCHEMBL3964933 | 0.79 | TBXAS1 (0.44) | HTR2CHTR2AHTR2BTBXAS1 | |
| Succinic Acid SCHEMBL10476179 | 0.76 | FFAR1 (0.42) | HTR2CHTR2AHTR2BPNMTADRA2A | |
| Succinic Acid SCHEMBL3971483 | 0.76 | HTR2A (0.41) | HTR2CHTR2AHTR2BPNMTADRA2A | |
| Succinic Acid SCHEMBL3971485 | 0.76 | HTR2A (0.41) | HTR2CHTR2AHTR2BPNMTADRA2A | |
| SCHEMBL3965071 | 0.76 | HTR2C (0.46) | HTR2CHTR2AHTR2BPNMTADRA2A | |
| Succinic Acid SCHEMBL2257679 | 0.76 | HTR2A (0.40) | HTR2CHTR2AHTR2BPNMTADRA2A | |
| Succinic Acid SCHEMBL2254527 | 0.75 | ALDH1A1 (0.45) | HTR2CHTR2AHTR2BTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420631-B2 | Serotonin receptor antagonist; therapy for obesity, antidepressants, obsessive-compulsive disorders | ELI LILLY AND COMPANY (US) | 2013-04-16 | — | — | US | disclosed |
| EP-1926712-B1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | LILLY CO ELI (US) | 2009-07-29 | — | — | EP | disclosed |
| US-20080207897-A1 | 6-Substituted-2,3,4,5-Tetrahydro-1H-Benzo[D] Azepines as 5-Ht2c Receptro Agonists | ELI LILLY AND COMPANY | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207897-A1 | 6-Substituted-2,3,4,5-Tetrahydro-1H-Benzo[D] Azepines as 5-Ht2c Receptro Agonists | HTR2C, HTR2A, HTR1A | HTR2C 1/4885HTR2A 2/4885DRD2 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.