Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.68 |
| ▸ | KDR | P35968 | 15/20 | 0.65 |
| ▸ | FLT1 | P17948 | 2/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.65 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.65 |
| ▸ | FLT4 | P35916 | 1/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.62 |
| ▸ | RET | P07949 | 5/20 | 0.59 |
| ▸ | KIF5B | P33176 | 5/20 | 0.59 |
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7118883 | 0.84 | SRC (0.74) | SRCKDRFLT1FGFR1EPHB2 | |
| SCHEMBL3962043 | 0.80 | SRC (0.62) | SRCKDRFLT1FGFR1EPHB2 | |
| SCHEMBL29365791 | 0.79 | KDR (1.00) | SRCKDRFLT1FGFR1EPHB2 | |
| SCHEMBL3012896 | 0.79 | KDR (1.00) | SRCKDRFLT1FGFR1EPHB2 | |
| Hydrochloric Acid SCHEMBL7867640 | 0.78 | KDR (0.98) | SRCKDRFLT1FGFR1EPHB2 | |
| Hydrochloric Acid SCHEMBL30078372 | 0.78 | KDR (0.98) | SRCKDRFLT1FGFR1EPHB2 | |
| SCHEMBL5477771 | 0.77 | KDR (1.00) | SRCKDRFLT1FLT4HDAC3 | |
| SCHEMBL11301337 | 0.77 | GRIK1 (0.60) | KDM4EMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL31067633 | 0.76 | KDR (0.82) | KDRFLT1HDAC3HDAC4HDAC1 | |
| SCHEMBL7117747 | 0.76 | KDR (0.71) | KDRFLT1FGFR1EPHB2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | claimed |
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |