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SCHEMBL3963155

SCHEMBL3963155

CC(=O)/C(=N\O)c1ccc(OCCCOc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 2/20 0.43
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ GAA P10253 3/20 0.36
▸ RAB9A P51151 2/20 0.33
▸ FURIN P09958 1/20 0.33
▸ PLA2G4B P0C869 1/20 0.33
▸ DPP4 P27487 1/20 0.32
▸ MAOA P21397 2/20 0.32
▸ MAOB P27338 2/20 0.32
▸ POLB P06746 1/20 0.32
▸ APEX1 P27695 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.32
▸ FFAR1 O14842 1/20 0.32
▸ FFAR4 Q5NUL3 1/20 0.32
▸ NPC1 O15118 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ TP53 P04637 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ ALOX15 P16050 1/20 0.32
▸ HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3963156 1.00 HTT (0.43) HTTL3MBTL1GAARAB9AFURIN
SCHEMBL3956305 0.90 HTT (0.41) HTTL3MBTL1GAAFURINPLA2G4B
SCHEMBL13606721 0.90 HTT (0.41) HTTL3MBTL1GAAFURINPLA2G4B
SCHEMBL3956304 0.90 HTT (0.41) HTTL3MBTL1GAAFURINPLA2G4B
SCHEMBL5690281 0.88 HTT (0.47) HTTL3MBTL1GAAPLA2G4BDPP4
SCHEMBL6548903 0.87 HTT (0.41) HTTL3MBTL1GAARAB9AFURIN
SCHEMBL6547877 0.87 L3MBTL1 (0.51) HTTL3MBTL1GAAMAOAMAOB
SCHEMBL6548880 0.85 HTT (0.41) HTTL3MBTL1GAARAB9AFURIN
SCHEMBL6548648 0.85 L3MBTL1 (0.55) HTTL3MBTL1GAAMAOAMAOB
SCHEMBL3185519 0.85 HTT (0.37) HTTL3MBTL1GAARAB9AFURIN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090298898-A1 PESTICIDALLY ACTIVE KETONE AND OXIME DERIVATIVES SYNGENTA CROP PROTECTION, INC. (US) 2009-12-03 — — US disclosed
US-7569727-B2 N-{(4-{3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propoxy}-phenyl)-[(E)-ethoxyimino]-methyl}-2,2,2-trifluoroacetamide; exhibit valuable preventive and/or curative activity even at low rates of concentration, while being well tolerated by warm-blooded animals, fish and plants SYNGENTA CROP PROTECTION, INC. (US) 2009-08-04 — — US disclosed
EP-2080752-A1 Pesticidally active ketone and oxime derivatives Syngenta Participations AG (CH) 2009-07-22 — — EP disclosed
US-20080200525-A1 PESTICIDALLY ACTIVE KETONE AND OXIME DERIVATIVES SYNGENTA CROP PROTECTION, INC. (US) 2008-08-21 — — US disclosed
US-20060128670-A1 Pesticidally active ketone and oxime derivatives SYNGENTA CROP PROTECTION, INC. 2006-06-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090298898-A1 PESTICIDALLY ACTIVE KETONE AND OXIME DERIVATIVES CHRM2, FOXO3, CHRM1 HTT 3825/4885L3MBTL1 469/4885GAA 3430/4885
US-20060128670-A1 Pesticidally active ketone and oxime derivatives CHRM2, CHRM1, DDT HTT 3632/4885L3MBTL1 401/4885GAA 3589/4885
US-20080200525-A1 PESTICIDALLY ACTIVE KETONE AND OXIME DERIVATIVES CHRM2, FOXO3, CHRM1 HTT 3825/4885L3MBTL1 469/4885GAA 3430/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.