Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | RHOA | P61586 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21926317 | 0.90 | HPGD (0.60) | HPGDRHOAMEN1KMT2AALDH1A1 | |
| SCHEMBL17913800 | 0.85 | MEN1 (0.68) | MEN1KMT2AALDH1A1KDM2BMAPK1 | |
| SCHEMBL3723522 | 0.84 | ALDH1A1 (0.61) | MEN1KMT2AALDH1A1KDM2BMAPK1 | |
| SCHEMBL3324359 | 0.84 | KDM2B (0.69) | ALDH1A1KDM2BL3MBTL1MGLL | |
| SCHEMBL4082779 | 0.84 | ALDH1A1 (0.61) | HPGDMEN1KMT2AALDH1A1KDM2B | |
| SCHEMBL3966828 | 0.84 | KDM2B (0.69) | ALDH1A1KDM2BL3MBTL1MGLL | |
| SCHEMBL16447329 | 0.83 | MGLL (0.64) | HPGDMEN1KMT2AALDH1A1HSD11B1 | |
| Hydrochloric Acid SCHEMBL6998897 | 0.83 | ALDH1A1 (0.60) | MEN1KMT2AALDH1A1KDM2BMAPK1 | |
| SCHEMBL2328924 | 0.83 | USP30 (0.53) | HPGDRHOAMEN1KMT2AALDH1A1 | |
| SCHEMBL2328921 | 0.83 | USP30 (0.53) | HPGDRHOAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101356156-B | Aspartic protease inhibitors | VITAE PHARMACEUTICALS INC | 2012-12-05 | — | — | CN | disclosed |
| EP-2081927-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| CN-101356156-A | Aspartic protease inhibitors | VITAE PHARMACEUTICALS INC (US) | 2009-01-28 | — | — | CN | disclosed |
| EP-1966139-A1 | ASPARTIC PROTEASE INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2008036216-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2007070201-A1 | ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |