SCHEMBL3963364

SCHEMBL3963364

FC(F)(F)Oc1c(Cl)ccc2[nH]nnc12

nearest known ligand 0.33

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17697482 0.72 GRM4 (0.37)
SCHEMBL5968352 0.71 GRM4 (0.32) NOTUM
SCHEMBL1426962 0.68 GRM4 (0.33)
SCHEMBL204111 0.68
SCHEMBL2995564 0.68 DPP4 (0.36)
SCHEMBL2883919 0.67 RHEB (0.31)
SCHEMBL2882436 0.67 KCNH2 (0.40)
SCHEMBL9172776 0.67 DPP4 (0.35)
SCHEMBL6052154 0.67 DPP4 (0.48) NOTUM
SCHEMBL11022639 0.66 ALPL (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11008416-B2 Aqueous, curable composition, comprising dispersed uretdione prepolymer, reactant and azolate COVESTRO LLC (US) 2021-05-18 US disclosed
EP-3768745-A1 URETDIONE-CONTAINING POLYURETHANE-DISPERSIONS COMPRISING HYDROPHILIC GROUPS Covestro Deutschland AG (DE) 2021-01-27 EP disclosed
EP-3768747-A1 AQUEOUS, CURABLE COMPOSITION, COMPRISING DISPERSED URETDIONE PREPOLYMER, REACTANT AND AZOLATE Covestro LLC (US) 2021-01-27 EP disclosed
US-20210017322-A1 URETDIONE-CONTAINING POLYURETHANE-DISPERSIONS COMPRISING HYDROPHILIC GROUPS COVESTRO DEUTSCHLAND AG (DE) 2021-01-21 US disclosed
CN-111886271-A Aqueous curable compositions comprising dispersed uretdione prepolymers, reactants, and azoles 科思创有限公司 2020-11-03 CN disclosed
CN-111868131-A Uretdione-containing polyurethane dispersions containing hydrophilic groups 科思创德国股份有限公司 2020-10-30 CN disclosed
WO-2019180130-A1 URETDIONE-CONTAINING POLYURETHANE-DISPERSIONS COMPRISING HYDROPHILIC GROUPS COVESTRO DEUTSCHLAND AG (DE) 2019-09-26 WO disclosed
WO-2019183300-A1 AQUEOUS, CURABLE COMPOSITION, COMPRISING DISPERSED URETDIONE PREPOLYMER, REACTANT AND AZOLATE COVESTRO LLC (US) 2019-09-26 WO disclosed
US-20190292299-A1 AQUEOUS, CURABLE COMPOSITION, COMPRISING DISPERSED URETDIONE PREPOLYMER, REACTANT AND AZOLATE COVESTRO LLC 2019-09-26 US disclosed
EP-3543269-A1 URETDIONE-CONTAINING POLYURETHANE-DISPERSIONS COMPRISING HYDROPHILIC GROUPS Covestro Deutschland AG (DE) 2019-09-25 EP disclosed
CN-1302038-C Method for producing aliphatic polyisocyanates having an uretdione, isocyanurate and imionooxadiazind-ione structure BAYER AG (DE) 2007-02-28 CN disclosed
US-7030266-B2 Method for producing polyisocyanates BAYER AKTIENGESELLSCHAFT (DE) 2006-04-18 US disclosed
CN-1509301-A Process for preparing aliphatic polyisocyanates having uretdione, isocyanurate and iminooxadiazinedione structures 2004-06-30 CN disclosed
EP-1389221-A1 METHOD FOR PRODUCING ALIPHATIC POLYISOCYANATES HAVING AN URETDIONE, ISOCYANURATE AND IMINOOXADIAZINDIONE STRUCTURE Bayer Aktiengesellschaft (DE) 2004-02-18 EP disclosed
EP-1389223-A1 METHOD FOR PRODUCING POLYISOCYANATES Bayer Aktiengesellschaft (DE) 2004-02-18 EP disclosed
US-6590098-B2 Reacting isocyanates-2+ such as hexamethylene diisocyanate in the presence of catalysts, to form dimers, trimers and/or adducts used as polyurethane paints and coatings BAYER AKTIENGESELLSCHAFT (DE) 2003-07-08 US disclosed
US-20030078450-A1 Method for producing polyisocyanates COVESTRO DEUTSCHLAND AG (DE) 2003-04-24 US disclosed
US-20030078361-A1 Method of preparing aliphatic polyisocyanates with uretdione, isocyanurate and iminooxadiazindione structures BAYER AKTIENGESELLSCHAFT (DE) 2003-04-24 US disclosed
WO-2002092658-A1 METHOD FOR PRODUCING POLYISOCYANATES BAYER AKTIENGESELLSCHAFT (DE) 2002-11-21 WO disclosed
WO-2002092656-A1 METHOD FOR PRODUCING ALIPHATIC POLYISOCYANATES HAVING AN URETDIONE, ISOCYANURATE AND IMINOOXADIAZINDIONE STRUCTURE BAYER AKTIENGESELLSCHAFT (DE) 2002-11-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030078450-A1 Method for producing polyisocyanates HDHD5, NISCH, DOHH NOTUM 271/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.