Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4972804 | 0.86 | REN (0.43) | TSHRMAPTCNR1CNR2SMN1; SMN2 | |
| SCHEMBL4972809 | 0.86 | REN (0.43) | TSHRMAPTCNR1CNR2SMN1; SMN2 | |
| SCHEMBL2327226 | 0.82 | CNR1 (0.46) | MAPTCNR1CNR2KMT2AALDH1A1 | |
| SCHEMBL2327230 | 0.82 | CNR1 (0.46) | MAPTCNR1CNR2KMT2AALDH1A1 | |
| SCHEMBL2327223 | 0.82 | CNR1 (0.46) | MAPTCNR1CNR2KMT2AALDH1A1 | |
| SCHEMBL4974841 | 0.81 | KMT2A (0.40) | TSHRMAPTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4974838 | 0.81 | KMT2A (0.40) | TSHRMAPTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14864959 | 0.79 | REN (0.42) | CNR1CNR2KMT2AALDH1A1MEN1 | |
| SCHEMBL12091032 | 0.75 | REN (0.43) | CNR1CNR2KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4073475 | 0.74 | REN (0.52) | MAPTSMN1; SMN2RENLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081927-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008036216-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |