Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 3/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPRA | P18433 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23856832 | 0.90 | PTPRB (0.30) | PTPRB | |
| SCHEMBL16994587 | 0.90 | ALDH1A1 (0.33) | PTPRB | |
| SCHEMBL30253243 | 0.89 | DGAT1 (0.34) | PTPRBDGAT1PTPN1PTPN2PTPRA | |
| SCHEMBL17358192 | 0.87 | — | — | |
| SCHEMBL20627096 | 0.87 | PTPRB (0.32) | PTPRBPTPN1PTPN2PTPRA | |
| SCHEMBL30253452 | 0.83 | ALDH1A1 (0.30) | — | |
| SCHEMBL14727963 | 0.82 | DGAT1 (0.37) | DGAT1CTSK | |
| SCHEMBL11449724 | 0.80 | DGAT1 (0.35) | DGAT1CTSK | |
| SCHEMBL13259166 | 0.78 | MEN1 (0.48) | — | |
| SCHEMBL3974919 | 0.74 | ALDH1A1 (0.38) | PTPRBDGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126855-B1 | COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS | HOFFMANN LA ROCHE (CH) | 2024-04-24 | — | — | EP | disclosed |
| US-20230167127-A1 | COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2023-06-01 | — | — | US | disclosed |
| US-20230167127-A1 | COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2023-06-01 | — | — | US | disclosed |
| US-20230167127-A1 | COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2023-06-01 | — | — | US | disclosed |
| EP-4126855-A1 | COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION | F. Hoffmann-La Roche AG (CH) | 2023-02-08 | — | — | EP | disclosed |
| CN-115298176-A | Compounds and their use in the treatment of bacterial infections | 豪夫迈·罗氏有限公司 | 2022-11-04 | — | — | CN | disclosed |
| WO-2021190727-A1 | COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2021-09-30 | — | — | WO | disclosed |
| WO-2021190727-A1 | COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2021-09-30 | — | — | WO | disclosed |
| US-9790187-B2 | Heterocyclic compounds | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2017-10-17 | — | — | US | disclosed |
| US-20150307455-A1 | HETEROCYCLIC COMPOUNDS | NATIONAL SCIENCE FOUNDATION | 2015-10-29 | — | — | US | disclosed |
| US-9102683-B2 | Heterocyclic compounds | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2015-08-11 | — | — | US | disclosed |
| WO-2009044130-A1 | BIARYL DIPHOSPHINES | UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307455-A1 | HETEROCYCLIC COMPOUNDS | CYP2C8, UGT1A8, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | PTPRB 3797/4885DGAT1 3093/4885PTPN1 4414/4885 |
| US-20230167127-A1 | COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION | LTB4R, C5, C3AR1 | PTPRB 1765/4885DGAT1 3509/4885PTPN1 3461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.