Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3879025 | 0.81 | LMNA (0.55) | CYP1A2CYP2D6CYP2C19LMNAPTGS2 | |
| SCHEMBL4237947 | 0.80 | PRMT5 (0.46) | ACKR3HDAC1ALDH1A1KDM4E | |
| SCHEMBL3955325 | 0.80 | CYP1A2 (0.41) | CYP1A2CYP2D6CYP2C19LMNAPTGS2 | |
| SCHEMBL3963784 | 0.78 | ALDH1A1 (0.49) | CYP1A2CYP2D6CYP2C19LMNAPTGS2 | |
| SCHEMBL3957616 | 0.77 | MAPT (0.49) | CYP1A2CYP2D6CYP2C19LMNAPTGS2 | |
| SCHEMBL3959182 | 0.73 | LMNA (0.52) | CYP1A2CYP2D6CYP2C19LMNAPTGS2 | |
| SCHEMBL580275 | 0.72 | NPC1 (0.56) | CYP1A2CYP2D6CYP2C19LMNAPTGS2 | |
| SCHEMBL3957834 | 0.69 | FAAH (0.58) | HDAC1MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL9315116 | 0.68 | LMNA (0.76) | CYP1A2CYP2D6CYP2C19LMNAPTGS2 | |
| SCHEMBL8267184 | 0.68 | HTT (0.74) | CYP1A2CYP2D6CYP2C19LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079525-A1 | CALCIUM RECEPTOR MODULATING AGENTS | Amgen Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008057282-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2008-05-15 | — | — | WO | disclosed |